The Bioscience Nuclear Microscopy Program at LLNL

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Since initiation in mid 1994, a bioscience nuclear microscopy program at Livermore has enabled collaboration with bio-scientists on a variety of projects requiring quantitative elemental microanalysis. For microprobe analysis a combination of PIXE and STIM are typically used; respectively generating element distribution maps with micron scale spatial resolution, and projected densities and histological information with sub-micron spatial resolution. Current studies demonstrate the applicability of nuclear microscopy (particularly when combined with other analysis techniques) in environmental tracing, toxicology, carcinogenesis, and structural biology. The program currently uses {approximately}10 percent of the available time on a 10 MV tandem accelerator that is also ... continued below

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15 p.

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Bench, G.; Freeman, S.; Roberts, M. & Sideras-Haddad, E. December 31, 1996.

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Description

Since initiation in mid 1994, a bioscience nuclear microscopy program at Livermore has enabled collaboration with bio-scientists on a variety of projects requiring quantitative elemental microanalysis. For microprobe analysis a combination of PIXE and STIM are typically used; respectively generating element distribution maps with micron scale spatial resolution, and projected densities and histological information with sub-micron spatial resolution. Current studies demonstrate the applicability of nuclear microscopy (particularly when combined with other analysis techniques) in environmental tracing, toxicology, carcinogenesis, and structural biology. The program currently uses {approximately}10 percent of the available time on a 10 MV tandem accelerator that is also applied to a variety of Accelerator Mass Spectrometry and other microprobe programs. The completion of a dedicated nuclear microprobe system, using a 5 SDH NEC 1.7 MV tandem accelerator and employing several energy dispersive x-ray detectors to improve x-ray counting rates, promises increased accelerator access, greater sample throughput and continued expansion of the program.

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15 p.

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OSTI as DE97050793

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  • 5. international conference on nuclear microprobe techniques and applications (ICNMTA-5), Santa Fe, NM (United States), 11-15 Nov 1996

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  • Other: DE97050793
  • Report No.: UCRL-JC--125560
  • Report No.: CONF-961120--2
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 441112
  • Archival Resource Key: ark:/67531/metadc675928

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Office of Scientific & Technical Information Technical Reports

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Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • December 31, 1996

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  • July 25, 2015, 2:21 a.m.

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  • Feb. 16, 2016, 2:34 p.m.

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Bench, G.; Freeman, S.; Roberts, M. & Sideras-Haddad, E. The Bioscience Nuclear Microscopy Program at LLNL, article, December 31, 1996; California. (digital.library.unt.edu/ark:/67531/metadc675928/: accessed July 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.