Chiral separation of pharmaceutical compounds using electrochemically modulated liquid chromatography (EMLC)

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This research explores the application of a new technique, termed electrochemically modulated liquid chromatography (EMLC), to the chiral separations of pharmaceutical compounds. The introduction section provides a literature review of the technique and its applications, as well as brief overview of the research described in each of the next two chapters. Chapter 2 investigates the EMLC-based enantiomeric separation of a group of chiral benzodiazepines with {beta}-cyclodextrin as a chiral mobile phase additive. Chapter 3 demonstrates the effects of several experimental parameters on the separation efficiency of drug enantiomers. The author concludes with a general summary and possible directions for future … continued below

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19 p.

Creation Information

Wang, S. February 12, 1999.

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This thesis or dissertation is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by the UNT Libraries Government Documents Department to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 113 times. More information about this document can be viewed below.

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  • Ames Laboratory
    Publisher Info: Ames Lab., IA (United States)
    Place of Publication: Iowa

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Description

This research explores the application of a new technique, termed electrochemically modulated liquid chromatography (EMLC), to the chiral separations of pharmaceutical compounds. The introduction section provides a literature review of the technique and its applications, as well as brief overview of the research described in each of the next two chapters. Chapter 2 investigates the EMLC-based enantiomeric separation of a group of chiral benzodiazepines with {beta}-cyclodextrin as a chiral mobile phase additive. Chapter 3 demonstrates the effects of several experimental parameters on the separation efficiency of drug enantiomers. The author concludes with a general summary and possible directions for future studies. Chapters 2 and 3 are processed separately.

Physical Description

19 p.

Notes

OSTI as DE99002527

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  • Other Information: DN: Thesis submitted to Iowa State Univ., Ames, IA (US); TH: Thesis (M.S.)

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  • Other: DE99002527
  • Report No.: IS-T--1846
  • Grant Number: W-7405-ENG-82
  • Office of Scientific & Technical Information Report Number: 348904
  • Archival Resource Key: ark:/67531/metadc675927

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • February 12, 1999

Added to The UNT Digital Library

  • July 25, 2015, 2:20 a.m.

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  • Nov. 6, 2015, 8:53 p.m.

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Wang, S. Chiral separation of pharmaceutical compounds using electrochemically modulated liquid chromatography (EMLC), thesis or dissertation, February 12, 1999; Iowa. (https://digital.library.unt.edu/ark:/67531/metadc675927/: accessed March 18, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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