Solubility in Binary Solvent Systems 1: Specific versus Nonspecific Interactions

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Article on the solubility in binary solvent systems I and the specific versus nonspecific interactions.

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5 p.

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Acree, William E. (William Eugene) & Rytting, J. Howard February 1, 1982.

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Article on the solubility in binary solvent systems I and the specific versus nonspecific interactions.

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5 p.

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Abstract: Solubilities are reported for benzil in carbon tetrachloride-alkane (isooctane, n-octane, cyclooctane) systems at 25 degrees and in similar binary mixtures containing cyclohexane plus alkane. The results of these measurements are compared to solution models previously developed for solubility in systems containing specific solute-solvent interactions and to models for purely nonspecific interactions. A stoichiometric complexation model based primarily on specific solute-solvent interactions requires several equilibrium constants to mathematically describe the experimental solubilities in binary carbon tetrachloride mixtures. However, there was no direct experimental evidence to suggest complexation between benzil and carbon tetrachloride. In comparison, expressions derived from the Nearly Ideal Binary Solvent (NIBS) model for nonspecific interactions predict experimental solubilities with a maximum deviation of 5% and an overall deviation of 1.0%. The success of the NIBS approach for this system is significant because the mole fraction solubility of benzil changes by a factor of 14 in the carbon tetrachloride-isooctane system.

© 1982 by the American Pharmaceutical Association.

"Solubility in Binary Solvent Systems 1."

Source

  • Journal of Pharmaceutical Sciences, 1982, Washington D.C.: American Pharmaceutical Association, pp. 201-205

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Publication Information

  • Publication Title: Journal of Pharmaceutical Sciences
  • Volume: 71
  • Issue: 2
  • Page Start: 201
  • Page End: 205
  • Peer Reviewed: Yes

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  • February 1, 1982

Submitted Date

  • February 24, 1981

Accepted Date

  • June 29, 1981

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  • July 9, 2015, 6:19 a.m.

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  • July 14, 2015, 11:39 a.m.

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Acree, William E. (William Eugene) & Rytting, J. Howard. Solubility in Binary Solvent Systems 1: Specific versus Nonspecific Interactions, article, February 1, 1982; [Washington, D.C.]. (digital.library.unt.edu/ark:/67531/metadc674092/: accessed September 23, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.