Solubility of Lamotrigine, Diazepam, and Clonazepam in Ethanol + Water Mixtures at 298.15 K

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Article on the solubility of lamotrigine, diazepam, and clonazepam in ethanol + water mixtures at 298.15 K.

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3 p.

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Shayanfar, Ali; Fakhree, Mohammad Amin Abolghassemi; Acree, William E. (William Eugene) & Jouyban, Abolghasem December 22, 2008.

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Article on the solubility of lamotrigine, diazepam, and clonazepam in ethanol + water mixtures at 298.15 K.

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3 p.

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Abstract: Experimental solubilities of three antiepileptic drugs, that is, lamotrigine, diazepam, and clonazepam in ethanol + water mixtures at 298.15 K were reported. The solubility of drugs was increased with the addition of ethanol, reached the maximum values, and then decreased with further increase in ethanol concentrations. The Jouyban−Acree model was fitted to the data, and the solubilities were reproduced using two previously developed relationships employing a number of the solvent’s and solute’s parameters and the solubility data in monosolvents in which the overall mean deviations (OMDs) of the models were 6.2 %, 22.3 %, and 23.2 %.

Reprinted with permission from the Journal of Chemical Engineering Data. Copyright 2008 American Chemical Society.

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  • Journal of Chemical and Engineering Data, 2008, Washington D.C.: American Chemical Society, pp. 1107-1109

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  • Publication Title: Journal of Chemical and Engineering Data
  • Volume: 54
  • Issue: 3
  • Page Start: 1107
  • Page End: 1109
  • Pages: 3
  • Peer Reviewed: Yes

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  • December 22, 2008

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  • July 9, 2015, 6:19 a.m.

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  • July 13, 2015, 4:33 p.m.

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Shayanfar, Ali; Fakhree, Mohammad Amin Abolghassemi; Acree, William E. (William Eugene) & Jouyban, Abolghasem. Solubility of Lamotrigine, Diazepam, and Clonazepam in Ethanol + Water Mixtures at 298.15 K, article, December 22, 2008; [Washington, D.C.]. (digital.library.unt.edu/ark:/67531/metadc674044/: accessed September 21, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.