Contribution of maternal radionuclide burdens to prenatal radiation doses

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This report describes approaches to calculating and expressing radiation doses to the embryo/fetus from internal radionuclides. Information was obtained for selected, occupationally significant radioelements that provide a spectrum of metabolic and dosimetric characteristics. Evaluations are also presented for inhaled inert gases and for selected radiopharmaceuticals. Fractional placental transfer and/or ratios of concentration in the embryo/fetus to that in the woman were calculated for these materials. The ratios were integrated with data from biokinetic transfer models to estimate radioactivity levels in the embryo/fetus as a function of stage of pregnancy and time after entry into the transfer compartment or blood of ... continued below

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388 p.

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Sikov, M.R. & Hui, T.E. May 1, 1996.

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  • Pacific Northwest Laboratory
    Publisher Info: Pacific Northwest Lab., Richland, WA (United States)
    Place of Publication: Richland, Washington

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Description

This report describes approaches to calculating and expressing radiation doses to the embryo/fetus from internal radionuclides. Information was obtained for selected, occupationally significant radioelements that provide a spectrum of metabolic and dosimetric characteristics. Evaluations are also presented for inhaled inert gases and for selected radiopharmaceuticals. Fractional placental transfer and/or ratios of concentration in the embryo/fetus to that in the woman were calculated for these materials. The ratios were integrated with data from biokinetic transfer models to estimate radioactivity levels in the embryo/fetus as a function of stage of pregnancy and time after entry into the transfer compartment or blood of the pregnant woman. These results are given as tables of deposition and retention in the embryo/fetus as a function of gestational age at exposure and elapsed time following exposure. Methodologies described by MIRD were extended to formalize and describe details for calculating radiation absorbed doses to the embryo/fetus. Calculations were performed using a model situation that assumed a single injection of 1 {mu}Ci into a woman`s blood; independent calculations were performed for administration at successive months of pregnancy. Gestational -stage-dependent dosimetric tabulations are given together with tables of correlations and relationships. Generalized surrogate dose factors and categorizations are provided in the report to provide for use in operational radiological protection situations. These approaches to calculation yield radiation absorbed doses that can be converted to dose equivalent by multiplication by quality factor. Dose equivalent is the most common quantity for stating prenatal dose limits in the United States and is appropriate for the types of effect that are usually associated with prenatal exposure. If it is desired to obtain alternatives for other purposes, this value can be multiplied by appropriate weighting factors.

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388 p.

Notes

INIS; OSTI as TI96011103

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  • Other Information: PBD: May 1996

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  • Other: TI96011103
  • Report No.: NUREG/CR--5631-Rev.2
  • Report No.: PNL--7445-Rev.2
  • Grant Number: AC06-76RL01830
  • DOI: 10.2172/239309 | External Link
  • Office of Scientific & Technical Information Report Number: 239309
  • Archival Resource Key: ark:/67531/metadc671724

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Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • May 1, 1996

Added to The UNT Digital Library

  • June 29, 2015, 9:42 p.m.

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  • April 7, 2016, 8:48 p.m.

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Sikov, M.R. & Hui, T.E. Contribution of maternal radionuclide burdens to prenatal radiation doses, report, May 1, 1996; Richland, Washington. (digital.library.unt.edu/ark:/67531/metadc671724/: accessed October 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.