Support of the IMA summer program molecular biology. Final report

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The revolutionary progress in molecular biology within the last 30 years opens the way to full understanding of the molecular structures and mechanisms of living organisms. The mathematical sciences accompany and support much of the progress achieved by experiment and computation, as well as provide insight into geometric and topological properties of biomolecular structure and processes. The 4 week program at the IMA brought together biologists and mathematicians leading researchers, postdocs, and graduate students. It focused on genetic mapping and DNA sequencing, followed by biomolecular structure and dynamics. High-resolution linkage maps of genetic marker were discussed extensively in relation to ... continued below

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4 p.

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Friedman, A. August 1, 1995.

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The revolutionary progress in molecular biology within the last 30 years opens the way to full understanding of the molecular structures and mechanisms of living organisms. The mathematical sciences accompany and support much of the progress achieved by experiment and computation, as well as provide insight into geometric and topological properties of biomolecular structure and processes. The 4 week program at the IMA brought together biologists and mathematicians leading researchers, postdocs, and graduate students. It focused on genetic mapping and DNA sequencing, followed by biomolecular structure and dynamics. High-resolution linkage maps of genetic marker were discussed extensively in relation to the human genome project. The next level of DNA mapping is physical mapping, consisting of overlapping clones spanning the genome. These maps are extremely useful for genetic analysis. They provide the material for less redundant sequencing and for detailed searches for a gene among other things. This topic was also extensively studied by the participants. From there, the program moved to consider protein structure and dynamics; this is a broad field with a large array of interesting topics. It is of key importance in answering basic scientific questions about the nature of all living organisms, and has practical biomedical applications. The major subareas of structure prediction and classification, techniques and heuristics for the simulation of protein folding, and molecular dynamics provide a rich problem domain where mathematics can be helpful in analysis, modeling, and simulation. One of the important problems in molecular biology is the three-dimensional structure of proteins, DNA and RNA in the cell, and the relationship between structure and function. The program helped increased the understanding of the topology of cellular DNA, RNA and proteins and the various life-sustaining mechanisms used by the cell which modify this molecular topology.

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4 p.

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OSTI as DE96003402

Medium: P; Size: 4 p.

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  • IMA summer program on molecular biology, Minneapolis, MN (United States), 5-29 Jul 1994

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  • Other: DE96003402
  • Report No.: DOE/ER/61884--1
  • Report No.: CONF-9407205--Final
  • Grant Number: FG02-94ER61884
  • Office of Scientific & Technical Information Report Number: 172083
  • Archival Resource Key: ark:/67531/metadc670903

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Office of Scientific & Technical Information Technical Reports

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  • August 1, 1995

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  • June 29, 2015, 9:42 p.m.

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  • April 13, 2017, 12:23 p.m.

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Friedman, A. Support of the IMA summer program molecular biology. Final report, article, August 1, 1995; United States. (digital.library.unt.edu/ark:/67531/metadc670903/: accessed May 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.