Computational modeling of laser thrombolysis for stroke treatment

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Many aspects of the physical process involved in a pulsed laser interacting with an occlusion in the intra-cranial vascular system are included in the simulation codes LATIS and LATIS3d. Laser light propagation and thermomechanical effects on the occlusion can be calculated by these codes. The hydrodynamic response uses a realistic equation of state which included melting and evaporation. Simple material strength and failure models now included in these codes are required to describe clot breakup. The goal is to ascertain the feasibility of laser thrombolysis, and to help optimize the laser parameters for such therapy. In this paper detailed numerical ... continued below

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13 p.

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Strauss, M.; Amendt, P.; London, R.A.; Maitland, D.J.; Glinsky, M.E.; Celliers, P. et al. February 1, 1996.

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Description

Many aspects of the physical process involved in a pulsed laser interacting with an occlusion in the intra-cranial vascular system are included in the simulation codes LATIS and LATIS3d. Laser light propagation and thermomechanical effects on the occlusion can be calculated by these codes. The hydrodynamic response uses a realistic equation of state which included melting and evaporation. Simple material strength and failure models now included in these codes are required to describe clot breakup. The goal is to ascertain the feasibility of laser thrombolysis, and to help optimize the laser parameters for such therapy. In this paper detailed numerical results for laser interaction with water is considered as an initial model for laser thrombolysis of soft blood clots which have high water content.

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13 p.

Notes

OSTI as DE96012233

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  • Photonics West `96: conference on quantum well and superlattice physics VI, San Jose, CA (United States), 27 Jan - 2 Feb 1996

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  • Other: DE96012233
  • Report No.: UCRL-JC--124045
  • Report No.: CONF-960163--33
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 266374
  • Archival Resource Key: ark:/67531/metadc670363

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Office of Scientific & Technical Information Technical Reports

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  • February 1, 1996

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  • June 29, 2015, 9:42 p.m.

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  • Feb. 16, 2016, 5:11 p.m.

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Strauss, M.; Amendt, P.; London, R.A.; Maitland, D.J.; Glinsky, M.E.; Celliers, P. et al. Computational modeling of laser thrombolysis for stroke treatment, article, February 1, 1996; California. (digital.library.unt.edu/ark:/67531/metadc670363/: accessed October 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.