Cancer of the melanocytic system

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Within reasonably homogenous populations, skin cancer increases toward low latitudes, but this association does not indicate the wavelength regions involved in cancer induction. At present, the only animal model suitable for determining the wavelengths effective in melanoma induction are certain inter- and intraspecies hybrids of the small fish, Xiphophorus. Genetic evidence indicates that the hybrids contain only one tumor suppressor gene and, therefore, are very sensitive to cancer induction by single exposures to light. 5-Day old fish were exposed in spectrophotometer cuvettes, to different monochromatic wavelengths and fluences. The fish were kept for two months in tanks shielded with yellow ... continued below

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3 p.

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Setlow, R.B. December 31, 1994.

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Within reasonably homogenous populations, skin cancer increases toward low latitudes, but this association does not indicate the wavelength regions involved in cancer induction. At present, the only animal model suitable for determining the wavelengths effective in melanoma induction are certain inter- and intraspecies hybrids of the small fish, Xiphophorus. Genetic evidence indicates that the hybrids contain only one tumor suppressor gene and, therefore, are very sensitive to cancer induction by single exposures to light. 5-Day old fish were exposed in spectrophotometer cuvettes, to different monochromatic wavelengths and fluences. The fish were kept for two months in tanks shielded with yellow plastic, so as to minimize the possibility of photoreactivation, and were scored at four months. The melanoma prevalence increased with exposure to a maximum of {approximately} 0.5. The fluence-response curves were fitted to surviving fraction = a+b(l-e{sup {minus}kE}), where a is the background prevalence with no exposure, b is the maximum induced prevalence, k is the sensitivity parameter (the cross section for melanoma induction), and E is the incident fluence. The value of k at 302 nm was 0.05 m{sup 2}/J giving a mean melanoma inducing exposure, for swimming fish, of 200 J/m{sup 2}, corresponding to 3.5 cyclobutane pyrimidine dimers per Mbp of DNA in irradiated fish skin.

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3 p.

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OSTI as DE96004162

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  • International symposiium on ozone, sun, cancer and molecular and cellular mechanisms and prevention, Paris (France), 17-20 May 1994

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  • Other: DE96004162
  • Report No.: BNL--62461
  • Report No.: CONF-9405134--2
  • Grant Number: AC02-76CH00016
  • Office of Scientific & Technical Information Report Number: 198693
  • Archival Resource Key: ark:/67531/metadc669427

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • December 31, 1994

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  • June 29, 2015, 9:42 p.m.

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  • Dec. 4, 2015, 10:33 p.m.

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Setlow, R.B. Cancer of the melanocytic system, article, December 31, 1994; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc669427/: accessed October 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.