A New Simplified System for the Evaluation of BNCT Pharmaceuticals

PDF Version Also Available for Download.

Description

A system for testing potential BNCT pharmaceuticals in cell cultures has been developed with the cooperation of Oak Ridge National Laboratory (ORNL), the University of Tennessee Chemistry Department and the University of Tennessee Nuclear Engineering Department. A BNCT test model has been established with the use of the human lung cancer cell line A 549. These cells were maintained in standard laboratory facilities and subjected to boronated chemicals. Following toxicity studies the human luug cancer cells were exposed to {sup 252}Cf neutron sources provided by the Radiochemical Engineering Development Center (REDC) at ORNL The isotope {sup 252}Cf performs effectively for ... continued below

Physical Description

4 p.

Creation Information

Byrne, T.E.; Kabalka, G.W.; Martin, R.C. & Miller, L.F. September 13, 1998.

Context

This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Sponsor

Publisher

Provided By

UNT Libraries Government Documents Department

Serving as both a federal and a state depository library, the UNT Libraries Government Documents Department maintains millions of items in a variety of formats. The department is a member of the FDLP Content Partnerships Program and an Affiliated Archive of the National Archives.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Description

A system for testing potential BNCT pharmaceuticals in cell cultures has been developed with the cooperation of Oak Ridge National Laboratory (ORNL), the University of Tennessee Chemistry Department and the University of Tennessee Nuclear Engineering Department. A BNCT test model has been established with the use of the human lung cancer cell line A 549. These cells were maintained in standard laboratory facilities and subjected to boronated chemicals. Following toxicity studies the human luug cancer cells were exposed to {sup 252}Cf neutron sources provided by the Radiochemical Engineering Development Center (REDC) at ORNL The isotope {sup 252}Cf performs effectively for BNCT applications. The neutron spectrum is similar to that of a reactor fission source with an average energy of 2.1 MeV. A 50 mg source of {sup 252}Cf moderated by water provides a source on the order of 1 x 10{sup 9} thermal neutrons/cm{sup 2}/sec at a distance of 3 cm. The half-life of {sup 252}Cf is 2.65 years, and thus may provide a simple and reliable source of neutrons for BNCT in locations without suitable nuclear reactors. The REDC of ORNL stores and processes the U.S. stockpile of {sup 252}Cf.

Physical Description

4 p.

Notes

INIS; OSTI as DE00001767

Medium: P; Size: 4 pages

Source

  • 8th International Symposium on Neutron Capture Therapy for Cancer, La Jolla, CA (US), 09/13/1998--09/18/1998

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

  • Report No.: ORNL/CP-100097
  • Report No.: DP 04 50 50 4
  • Grant Number: AC05-96OR22464
  • Office of Scientific & Technical Information Report Number: 1767
  • Archival Resource Key: ark:/67531/metadc667404

Collections

This article is part of the following collection of related materials.

Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Creation Date

  • September 13, 1998

Added to The UNT Digital Library

  • June 29, 2015, 9:42 p.m.

Description Last Updated

  • April 10, 2017, 7:58 p.m.

Usage Statistics

When was this article last used?

Yesterday: 0
Past 30 days: 0
Total Uses: 2

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Byrne, T.E.; Kabalka, G.W.; Martin, R.C. & Miller, L.F. A New Simplified System for the Evaluation of BNCT Pharmaceuticals, article, September 13, 1998; Tennessee. (digital.library.unt.edu/ark:/67531/metadc667404/: accessed October 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.