HIV transcription is induced in dying cells Metadata

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Title

  • Main Title HIV transcription is induced in dying cells

Creator

  • Author: Woloschak, Gayle E.
    Creator Type: Personal
  • Author: Chang-Liu, Chin-Mei
    Creator Type: Personal
    Creator Info: Argonne National Lab., IL (United States)
  • Author: Schreck, Steven
    Creator Type: Personal
    Creator Info: Univ. of South Carolina, Columbia, SC (United States). Dept. of Chemistry
  • Author: Panozzo, John
    Creator Type: Personal
    Creator Info: Loyola Univ. Medical Center, Maywood, IL (United States)
  • Author: Libertin, Claudia R.
    Creator Type: Personal
    Creator Info: Loyola Univ. Medical Center, Maywood, IL (United States)

Contributor

  • Sponsor: United States. Department of Energy.
    Contributor Type: Organization
    Contributor Info: USDOE, Washington, DC (United States)

Publisher

  • Name: Argonne National Laboratory
    Place of Publication: Illinois
    Additional Info: Argonne National Lab., IL (United States)

Date

  • Creation: 1996-02-01

Language

  • English

Description

  • Content Description: Using HeLa cells stably transfected with an HIV-LTR-CAT construct, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires functional p53, which is not present in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture. Doses which caused over 99% cell killing induced HIV-LTR transcription maximally, demonstrating that cells that will go on to die by 14 days are the cells expressing HIV-LTR-CAT.
  • Physical Description: 19 p.

Subject

  • Keyword: Ultraviolet Radiation
  • Keyword: Aids Virus
  • Keyword: Gene Regulation
  • Keyword: Transcription
  • STI Subject Categories: 55 Biology And Medicine, Basic Studies
  • Keyword: Hela Cells
  • Keyword: Reproduction
  • Keyword: Enzyme Induction
  • Keyword: Cell Killing

Source

  • Other Information: PBD: [1996]

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report

Format

  • Text

Identifier

  • Other: DE96007378
  • Report No.: ANL/CMB/PP--88224
  • Grant Number: W-31109-ENG-38
  • DOI: 10.2172/205111
  • Office of Scientific & Technical Information Report Number: 205111
  • Archival Resource Key: ark:/67531/metadc667314

Note

  • Display Note: OSTI as DE96007378
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