A biological microcavity laser

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Description

We have demonstrated a new semiconductor laser device that may be useful in high speed characterization of cell morphology for diagnosis of disease. This laser device has critical advantages over conventional cell fluorescence detection methods since it provides intense, monochromatic, low divergence light signals that are emitted from lasing modes confined by a cell. Further, the device integrates biological structures with semiconductor materials at the wafer level to reduce size and simplify cell preparation. This microcavity semiconductor laser comprises a vertical cavity surface-emitting semiconductor, to provide gain and feedback for light confined by cells, and a dielectric mirror to close ... continued below

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7 p.

Creation Information

Gourley, P.L. & Gourley, M.F. February 1, 1996.

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This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 47 times . More information about this article can be viewed below.

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  • Gourley, P.L. Sandia National Labs., Albuquerque, NM (United States)
  • Gourley, M.F. National Insts. of Health, Bethesda, MD (United States)

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  • Sandia National Laboratories
    Publisher Info: Sandia National Labs., Albuquerque, NM (United States)
    Place of Publication: Albuquerque, New Mexico

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Description

We have demonstrated a new semiconductor laser device that may be useful in high speed characterization of cell morphology for diagnosis of disease. This laser device has critical advantages over conventional cell fluorescence detection methods since it provides intense, monochromatic, low divergence light signals that are emitted from lasing modes confined by a cell. Further, the device integrates biological structures with semiconductor materials at the wafer level to reduce size and simplify cell preparation. This microcavity semiconductor laser comprises a vertical cavity surface-emitting semiconductor, to provide gain and feedback for light confined by cells, and a dielectric mirror to close the cavity. Transparent cells loaded into the cavity act as dielectric waveguides to define transverse electromagnetic modes. Light emitted from the microcavity can be resolved into narrow spectral modes, high-contrast/coherent light images, or time-dependent pulses that reveal cell morphology and size. We have used this laser device as a cytometer in two basic configurations. First, as a probe of individual cells by spectral analysis of cell modes. Second, as scanning cytometer for rapidly probing large numbers of cells by pulse height spectroscopy.

Physical Description

7 p.

Notes

OSTI as DE96007324

Source

  • 20. international congress on quantum electronics, Sydney (Australia), 14-19 Jul 1996

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  • Other: DE96007324
  • Report No.: SAND--96-0066C
  • Report No.: CONF-960707--1
  • Grant Number: AC04-94AL85000
  • Office of Scientific & Technical Information Report Number: 234690
  • Archival Resource Key: ark:/67531/metadc666804

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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Creation Date

  • February 1, 1996

Added to The UNT Digital Library

  • June 29, 2015, 9:42 p.m.

Description Last Updated

  • April 13, 2016, 1 p.m.

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Gourley, P.L. & Gourley, M.F. A biological microcavity laser, article, February 1, 1996; Albuquerque, New Mexico. (digital.library.unt.edu/ark:/67531/metadc666804/: accessed April 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.