Primate polonium metabolic models and their use in estimation of systemic radiation doses from bioassay data. Final report

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A Polonium metabolic model was derived and incorporated into a Fortran algorithm which estimates the systemic radiation dose from {sup 210}Po when applied to occupational urine bioassay data. The significance of the doses estimated are examined by defining the degree of uncertainty attached to them through comprehensive statistical testing procedures. Many parameters necessary for dosimetry calculations (such as organ partition coefficients and excretion fractions), were evaluated from metabolic studies of {sup 210}Po in non-human primates. Two tamarins and six baboons were injected intravenously with {sup 210}Po citrate. Excreta and blood samples were collected. Five of the baboons were sacrificed at ... continued below

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194 p.

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Cohen, N. March 15, 1989.

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  • Cohen, N. New York Univ. Medical Center, Tuxedo, NY (United States). Dept. of Environmental Medicine

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A Polonium metabolic model was derived and incorporated into a Fortran algorithm which estimates the systemic radiation dose from {sup 210}Po when applied to occupational urine bioassay data. The significance of the doses estimated are examined by defining the degree of uncertainty attached to them through comprehensive statistical testing procedures. Many parameters necessary for dosimetry calculations (such as organ partition coefficients and excretion fractions), were evaluated from metabolic studies of {sup 210}Po in non-human primates. Two tamarins and six baboons were injected intravenously with {sup 210}Po citrate. Excreta and blood samples were collected. Five of the baboons were sacrificed at times ranging from 1 day to 3 months post exposure. Complete necropsies were performed and all excreta and the majority of all skeletal and tissue samples were analyzed radiochemically for their {sup 210}Po content. The {sup 210}Po excretion rate in the baboon was more rapid than in the tamarin. The biological half-time of {sup 210}Po excretion in the baboon was approximately 15 days while in the tamarin, the {sup 210}Po excretion rate was in close agreement with the 50 day biological half-time predicted by ICRP 30. Excretion fractions of {sup 210}Po in the non-human primates were found to be markedly different from data reported elsewhere in other species, including man. A thorough review of the Po urinalysis procedure showed that significant recovery losses resulted when metabolized {sup 210}Po was deposited out of raw urine. Polonium-210 was found throughout the soft tissues of the baboon but not with the partition coefficients for liver, kidneys, and spleen that are predicted by the ICRP 30 metabolic model. A fractional distribution of 0.29 for liver, 0.07 for kidneys, and 0.006 for spleen was determined. Retention times for {sup 210}Po in tissues are described by single exponential functions with biological half-times ranging from 15 to 50 days.

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194 p.

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OSTI as DE96013865

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  • Other Information: PBD: 15 Mar 1989

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  • Other: DE96013865
  • Report No.: MLM-MU--89-65-0010
  • Grant Number: AC04-76DP00053
  • DOI: 10.2172/283755 | External Link
  • Office of Scientific & Technical Information Report Number: 283755
  • Archival Resource Key: ark:/67531/metadc666569

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  • March 15, 1989

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  • June 29, 2015, 9:42 p.m.

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  • Nov. 24, 2015, 7:53 p.m.

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Cohen, N. Primate polonium metabolic models and their use in estimation of systemic radiation doses from bioassay data. Final report, report, March 15, 1989; United States. (digital.library.unt.edu/ark:/67531/metadc666569/: accessed October 22, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.