Evaluation of the metabolic fate of munitions material (TNT & RDX) in plant systems and initial assessment of material interaction with plant genetic material (DNA). Initial assessment of plant DNA adducts as biomarkers Metadata

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Title

  • Main Title Evaluation of the metabolic fate of munitions material (TNT & RDX) in plant systems and initial assessment of material interaction with plant genetic material (DNA). Initial assessment of plant DNA adducts as biomarkers

Creator

  • Author: Harvey, S.D.
    Creator Type: Personal
  • Author: Clauss, T.W.
    Creator Type: Personal
  • Author: Fellows, R.J.
    Creator Type: Personal
  • Author: Cataldo, D.A.
    Creator Type: Personal

Contributor

  • Sponsor: United States. Department of Defense.
    Contributor Type: Organization
    Contributor Info: Department of Defense, Washington, DC (United States)

Publisher

  • Name: Pacific Northwest Laboratory
    Place of Publication: Richland, Washington
    Additional Info: Pacific Northwest Lab., Richland, WA (United States)

Date

  • Creation: 1995-08-01

Language

  • English

Description

  • Content Description: Genetic damage to deoxyribonucleic acid (DNA) has long been suspected of being a fundamental event leading to cancer. A variety of causal factors can result in DNA damage including photodimerization of base pairs, ionizing radiation, specific reaction of DNA with environmental pollutants, and nonspecific oxidative damage caused by the action of highly reactive oxidizing agents produced by metabolism. Because organisms depend on an unadulterated DNA template for reproduction, DNA repair mechanisms are an important defense for maintaining genomic integrity. The objective of this exploratory project was to evaluate the potential for TNT to form DNA adducts in plants. These adducts, if they exist in sufficient quantities, could be potential biomarkers of munitions exposure. The ultimate goal is to develop a simple analytical assay for the determination of blomarkers that is indicative of munitions contamination. DNA repair exists in dynamic equilibrium with DNA damage. Repair mechanisms are capable of keeping DNA damage at remarkably low concentrations provided that the repair capacity is not overwhelmed.
  • Physical Description: 27 p.

Subject

  • Keyword: Plants
  • Keyword: Genetics
  • Keyword: Tnt
  • Keyword: Pollution
  • STI Subject Categories: 55 Biology And Medicine, Basic Studies
  • Keyword: Soils
  • STI Subject Categories: 56 Biology And Medicine, Applied Studies
  • Keyword: Metabolism
  • Keyword: Biological Effects
  • STI Subject Categories: 45 Military Technology, Weaponry, And National Defense

Source

  • Other Information: PBD: Aug 1995

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report

Format

  • Text

Identifier

  • Other: DE96003998
  • Report No.: PNL--10738
  • Grant Number: AC06-76RL01830
  • DOI: 10.2172/195771
  • Office of Scientific & Technical Information Report Number: 195771
  • Archival Resource Key: ark:/67531/metadc665793

Note

  • Display Note: OSTI as DE96003998