New technetium-99m generator technologies utilizing polyethylene glycol-based aqueous biphasic systems

PDF Version Also Available for Download.

Description

Two new schemes for TcO{sub 4}{sup {minus}}/MoO{sub 4}{sup 2{minus}} separations from OH{sup {minus}} and MoO{sub 4}{sup 2{minus}} media using polyethylene glycol (PEG)-based aqueous biphasic systems (ABS) have been developed. The two most important salt solutions in current {sup 99m}Tc-generator technologies, OH{sup {minus}} and MoO{sub 4}{sup 2{minus}}, also salt out PEG to form ABS. In liquid/liquid PEG- ABS, pertechnetate can be separated from molybdate with separation factors as high as 10,000. Stripping is accomplished by reduction of the TcO{sub 4}{sup {minus}} and back extraction into a salt solution. the strip solution can be the salt of an imaging agent (e.g., Na{sub ... continued below

Physical Description

20 p.

Creation Information

Rogers, R.D.; Bond, A.H.; Zhang, Jianhua & Horwitz, P. December 31, 1995.

Context

This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 41 times . More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Authors

Sponsors

Publisher

Provided By

UNT Libraries Government Documents Department

Serving as both a federal and a state depository library, the UNT Libraries Government Documents Department maintains millions of items in a variety of formats. The department is a member of the FDLP Content Partnerships Program and an Affiliated Archive of the National Archives.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Description

Two new schemes for TcO{sub 4}{sup {minus}}/MoO{sub 4}{sup 2{minus}} separations from OH{sup {minus}} and MoO{sub 4}{sup 2{minus}} media using polyethylene glycol (PEG)-based aqueous biphasic systems (ABS) have been developed. The two most important salt solutions in current {sup 99m}Tc-generator technologies, OH{sup {minus}} and MoO{sub 4}{sup 2{minus}}, also salt out PEG to form ABS. In liquid/liquid PEG- ABS, pertechnetate can be separated from molybdate with separation factors as high as 10,000. Stripping is accomplished by reduction of the TcO{sub 4}{sup {minus}} and back extraction into a salt solution. the strip solution can be the salt of an imaging agent (e.g., Na{sub 4}HEDPA) and thus may, under the appropriate conditions, be injected directly into the human body. {sup 99m}TcO{sub 4}{sup {minus}} can also be concentrated from a dilute load solution of {sup 99}MoO{sub 4}{sup 2{minus}} in NaOH using an aqueous biphasic extraction chromatographic technique (ABEC). A rinse with K{sub 2}CO{sub 3} assures that all {sup 99}MoO{sub 4}{sup 2{minus}} is removed from the column and this is confirmed by a rapid drop in {sup 99}Mo activity by the fourth free column volume (fcv) of rinse. The {sup 99m}TcO{sub 4}{sup {minus}} is then eluted with water. This chromatographic separation affords 94% of the {sup 99m}TcO{sub 4}{sup {minus}} activity in 5 fcv, with the y spectrum showing less than 2 {times} 10{sup {minus}4} of the original {sup 99}Mo activity.

Physical Description

20 p.

Notes

INIS; OSTI as DE96006735

Source

  • 9. symposium on separation science and technology for energy applications, Gatlinburg, TN (United States), 22-26 Oct 1995

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

  • Other: DE96006735
  • Report No.: ANL/CHM/CP--89089
  • Report No.: CONF-951057--10
  • Grant Number: W-31-109-ENG-38
  • Office of Scientific & Technical Information Report Number: 207484
  • Archival Resource Key: ark:/67531/metadc665627

Collections

This article is part of the following collection of related materials.

Office of Scientific & Technical Information Technical Reports

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Creation Date

  • December 31, 1995

Added to The UNT Digital Library

  • June 29, 2015, 9:42 p.m.

Description Last Updated

  • Aug. 23, 2016, 3:40 p.m.

Usage Statistics

When was this article last used?

Yesterday: 0
Past 30 days: 2
Total Uses: 41

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

Citations, Rights, Re-Use

Rogers, R.D.; Bond, A.H.; Zhang, Jianhua & Horwitz, P. New technetium-99m generator technologies utilizing polyethylene glycol-based aqueous biphasic systems, article, December 31, 1995; Illinois. (digital.library.unt.edu/ark:/67531/metadc665627/: accessed September 22, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.