Mineralogical and geochemical aspects of mineral-induced disease

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Description

Many minerals are known to cause disease following inhalation, including asbestos, silica, zeolites, and clays. The mineralogical properties that determine toxicity are not known, hindering effective risk assessment. Consequently, many minerals that do not pose risks are controlled excessively and many minerals that do pose risk remain uncontrolled. The authors are integrating mineralogy and biology in an interdisciplinary scientific investigation of the mechanisms of mineral-induced disease. The biological endpoints include the formation of ferruginous bodies and chemical signaling (e.g., production of cytokines or active oxygen species) by cells; the mineralogical variables include structure, composition, and surface properties. The authors are ... continued below

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6 p.

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Guthrie, G.; Raymond, R.; Saffiotti, U.; Aust, A. & Mossman, B. April 1, 1996.

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Description

Many minerals are known to cause disease following inhalation, including asbestos, silica, zeolites, and clays. The mineralogical properties that determine toxicity are not known, hindering effective risk assessment. Consequently, many minerals that do not pose risks are controlled excessively and many minerals that do pose risk remain uncontrolled. The authors are integrating mineralogy and biology in an interdisciplinary scientific investigation of the mechanisms of mineral-induced disease. The biological endpoints include the formation of ferruginous bodies and chemical signaling (e.g., production of cytokines or active oxygen species) by cells; the mineralogical variables include structure, composition, and surface properties. The authors are also determining what information about the biological reaction is preserved in the mineral surface.

Physical Description

6 p.

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OSTI as DE96008328

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  • Other Information: PBD: [1996]

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  • Other: DE96008328
  • Report No.: LA-UR--96-1005
  • Grant Number: W-7405-ENG-36
  • DOI: 10.2172/212497 | External Link
  • Office of Scientific & Technical Information Report Number: 212497
  • Archival Resource Key: ark:/67531/metadc665203

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  • April 1, 1996

Added to The UNT Digital Library

  • June 29, 2015, 9:42 p.m.

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  • Feb. 25, 2016, 8:59 p.m.

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Guthrie, G.; Raymond, R.; Saffiotti, U.; Aust, A. & Mossman, B. Mineralogical and geochemical aspects of mineral-induced disease, report, April 1, 1996; New Mexico. (digital.library.unt.edu/ark:/67531/metadc665203/: accessed August 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.