Vertical cavity surface-emitting laser scanning cytometer for high speed analysis of cells

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We have constructed a new semiconductor laser device that may be useful in high speed characterization of cell morphology for diagnosis of disease. This laser device has critical advantages over conventional cell fluorescence detection methods since it provides intense, monochromatic, low-divergence fight signals that are emitted from lasing modes confined by a cell. Further, the device integrates biological structures with semiconductor materials at the wafer level to reduce device size and simplify cell preparation. In this paper we discuss operational characteristics of the prototype cytometer and present preliminary data for blood cells and dielectric spheres.

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14 p.

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Gourley, P. L.; McDonald, A. E. & Gourley, M. F. December 31, 1995.

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This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by the UNT Libraries Government Documents Department to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 33 times. More information about this article can be viewed below.

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  • Sandia National Laboratories
    Publisher Info: Sandia National Labs., Albuquerque, NM (United States)
    Place of Publication: Albuquerque, New Mexico

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Description

We have constructed a new semiconductor laser device that may be useful in high speed characterization of cell morphology for diagnosis of disease. This laser device has critical advantages over conventional cell fluorescence detection methods since it provides intense, monochromatic, low-divergence fight signals that are emitted from lasing modes confined by a cell. Further, the device integrates biological structures with semiconductor materials at the wafer level to reduce device size and simplify cell preparation. In this paper we discuss operational characteristics of the prototype cytometer and present preliminary data for blood cells and dielectric spheres.

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14 p.

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OSTI as DE96007414

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  • Photonics West `96: conference on quantum well and superlattice physics VI, San Jose, CA (United States), 27 Jan - 2 Feb 1996

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  • Other: DE96007414
  • Report No.: SAND--95-2970C
  • Report No.: CONF-960163--1
  • Grant Number: AC04-94AL85000
  • Office of Scientific & Technical Information Report Number: 205932
  • Archival Resource Key: ark:/67531/metadc663844

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Office of Scientific & Technical Information Technical Reports

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  • December 31, 1995

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  • June 29, 2015, 9:42 p.m.

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  • June 15, 2020, 1:51 p.m.

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Gourley, P. L.; McDonald, A. E. & Gourley, M. F. Vertical cavity surface-emitting laser scanning cytometer for high speed analysis of cells, article, December 31, 1995; Albuquerque, New Mexico. (https://digital.library.unt.edu/ark:/67531/metadc663844/: accessed April 24, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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