Isozymes and In Vivo Activity of Triosephosphate Isomerase

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The distribution of isozymes of triosephosphate isomerase was normal in all human tissues examined. This finding argues against the existence of tissue-specific isozymes. Normal distributions of isozymes were also found in patients with cri-du-chat syndrome. Thus it is unlikely that a gene for triosephosphate isomerase is located on the short arm of chromosome five in man. When triosephosphate isomerases from a wide range of species were examined by starch gel electrophoresis, definite evolutionary patterns were found. Kinetic studies were conducted on human triosephosphate isomerase under conditions simulating the intracellular environment of the erythrocyte. Calculations using the kinetic parameters obtained indicate ... continued below

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68 leaves: ill.

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Snapka, Robert Morris May 1974.

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  • Snapka, Robert Morris

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The distribution of isozymes of triosephosphate isomerase was normal in all human tissues examined. This finding argues against the existence of tissue-specific isozymes. Normal distributions of isozymes were also found in patients with cri-du-chat syndrome. Thus it is unlikely that a gene for triosephosphate isomerase is located on the short arm of chromosome five in man. When triosephosphate isomerases from a wide range of species were examined by starch gel electrophoresis, definite evolutionary patterns were found. Kinetic studies were conducted on human triosephosphate isomerase under conditions simulating the intracellular environment of the erythrocyte. Calculations using the kinetic parameters obtained indicate that even in triosephosphate isomerase deficiency disease, enough enzyme activity remains that the rate of glycolysis should not become inhibited.

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68 leaves: ill.

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  • May 1974

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  • June 24, 2015, 9:39 a.m.

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  • Aug. 23, 2016, 4:52 p.m.

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Snapka, Robert Morris. Isozymes and In Vivo Activity of Triosephosphate Isomerase, thesis, May 1974; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc663801/: accessed October 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .