X-irradiation Effects on the Action Potentials of Frog Sciatic Nerves Inhibited by Carbon Monoxide and Ouabain Metadata
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- Main Title X-irradiation Effects on the Action Potentials of Frog Sciatic Nerves Inhibited by Carbon Monoxide and Ouabain
Author: Thompson, Wesley J.Creator Type: Personal
Chair: Lott, James R.Contributor Type: PersonalContributor Info: Major Professor
Committee Member: Norton, S. J.Contributor Type: PersonalContributor Info: Minor Professor
Committee Member: Harris, Ben G.Contributor Type: Personal
Name: North Texas State UniversityPlace of Publication: Denton, TexasAdditional Info: www.unt.edu
- Creation: 1971-12
- Content Description: The response of frog sciatic nerve action potentials to x-irradiation and metabolic (carbon monoxide) or transport (ouabain) inhibition was determined in an attempt to further identify the nature of radiation insult to nervous tissue. Carbon monoxide, ouabain (2 X 10-5 M), and nitrogen anoxia were shown to produce a near linear decline in action potential amplitude. The carbon monoxide and nitrogen inhibitions of activity were reversible in air; the carbon monoxide inhibition was light reversible. Ouabain inhibition was partially reversible by soaking the nerve in aerated Ringer's. Application of 120 kv x-rays (75 Kr at 4.9 Kr/min) to nerves during the linear decline in spike amplitude brought about a marked enhancement (146%) of inhibition by 99% CO/l% 02, nitrogen (136%), and ouabain (265%). All bhanges were shown to be statistically significant by a regression analysis. However, x-irradiation did not appear to alter the air reversibility of carbon monoxide and nitrogen inhibitions nor the reversibility in Ringerts of the ouabain inhibition. Additionally x-irradiation completely blocked light reversal of 98% CO/2% 02 inhibition and produced a decline in activity. A possible interpretation of these results is a compensation for radiation action at this dosage requiring metabolism and ion pump activity.
- Physical Description: v, 58 leaves: ill.
- Keyword: carbon monoxide
- Keyword: nitrogen inhibitions
- Keyword: ouabain inhibition
Name: UNT Theses and DissertationsCode: UNTETD
Name: UNT LibrariesCode: UNT
- Rights Access: public
- Rights Holder: Thompson, Wesley J.
- Rights License: copyright
- Rights Statement: Copyright is held by the author, unless otherwise noted. All rights
- Thesis or Dissertation
- Accession or Local Control No: 1002774114-Thompson
- Call Number: 379 N81 no.4425
- UNT Catalog No.: b2217666
- Archival Resource Key: ark:/67531/metadc663400
- Academic Department: Department of Biological Sciences
- Degree Discipline: Biology
- Degree Level: Master's
- Degree Name: Master of Arts
- Degree Publication Type: thesi
- Degree Grantor: North Texas State University