X-irradiation Effects on the Action Potentials of Frog Sciatic Nerves Inhibited by Carbon Monoxide and Ouabain Metadata

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Title

  • Main Title X-irradiation Effects on the Action Potentials of Frog Sciatic Nerves Inhibited by Carbon Monoxide and Ouabain

Creator

  • Author: Thompson, Wesley J.
    Creator Type: Personal

Contributor

  • Chair: Lott, James R.
    Contributor Type: Personal
    Contributor Info: Major Professor
  • Committee Member: Norton, S. J.
    Contributor Type: Personal
    Contributor Info: Minor Professor
  • Committee Member: Harris, Ben G.
    Contributor Type: Personal

Publisher

  • Name: North Texas State University
    Place of Publication: Denton, Texas
    Additional Info: www.unt.edu

Date

  • Creation: 1971-12

Language

  • English

Description

  • Content Description: The response of frog sciatic nerve action potentials to x-irradiation and metabolic (carbon monoxide) or transport (ouabain) inhibition was determined in an attempt to further identify the nature of radiation insult to nervous tissue. Carbon monoxide, ouabain (2 X 10-5 M), and nitrogen anoxia were shown to produce a near linear decline in action potential amplitude. The carbon monoxide and nitrogen inhibitions of activity were reversible in air; the carbon monoxide inhibition was light reversible. Ouabain inhibition was partially reversible by soaking the nerve in aerated Ringer's. Application of 120 kv x-rays (75 Kr at 4.9 Kr/min) to nerves during the linear decline in spike amplitude brought about a marked enhancement (146%) of inhibition by 99% CO/l% 02, nitrogen (136%), and ouabain (265%). All bhanges were shown to be statistically significant by a regression analysis. However, x-irradiation did not appear to alter the air reversibility of carbon monoxide and nitrogen inhibitions nor the reversibility in Ringerts of the ouabain inhibition. Additionally x-irradiation completely blocked light reversal of 98% CO/2% 02 inhibition and produced a decline in activity. A possible interpretation of these results is a compensation for radiation action at this dosage requiring metabolism and ion pump activity.
  • Physical Description: v, 58 leaves: ill.

Subject

  • Keyword: carbon monoxide
  • Keyword: nitrogen inhibitions
  • Keyword: ouabain inhibition

Collection

  • Name: UNT Theses and Dissertations
    Code: UNTETD

Institution

  • Name: UNT Libraries
    Code: UNT

Rights

  • Rights Access: public
  • Rights Holder: Thompson, Wesley J.
  • Rights License: copyright
  • Rights Statement: Copyright is held by the author, unless otherwise noted. All rights

Resource Type

  • Thesis or Dissertation

Format

  • Text

Identifier

  • Accession or Local Control No: 1002774114-Thompson
  • Call Number: 379 N81 no.4425
  • UNT Catalog No.: b2217666
  • Archival Resource Key: ark:/67531/metadc663400

Degree

  • Academic Department: Department of Biological Sciences
  • Degree Discipline: Biology
  • Degree Level: Master's
  • Degree Name: Master of Arts
  • Degree Publication Type: thesi
  • Degree Grantor: North Texas State University

Note