Studies of L-Asparaginase from Lactobacillus Plantarum

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This study is concerned with the regulation of Lasparaginase (LA) in the cell-free crude extracts from Lactobacillus plantarum (ATCC8014). A previously reported finding that adenosine triphosphate (ATP) inhibits the action of LA in crude extracts was confirmed. The study was extended to include the mono-, di-, and triphosphates of adenosine, guanosine, cytidine, and uridine. These compounds were also shown to inhibit LA activity. These andother studies revealed that LA appears to be an allosteric type enzyme exhibiting positive homotropism with respect to substrate and heterotropism with respect to the nucleotides tested. The regulation of LA activity by high energy compounds, ... continued below

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vii, 56 p. : ill.

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Nalepka, Edward R. May 1979.

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  • Nalepka, Edward R.

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Description

This study is concerned with the regulation of Lasparaginase (LA) in the cell-free crude extracts from Lactobacillus plantarum (ATCC8014). A previously reported finding that adenosine triphosphate (ATP) inhibits the action of LA in crude extracts was confirmed. The study was extended to include the mono-, di-, and triphosphates of adenosine, guanosine, cytidine, and uridine. These compounds were also shown to inhibit LA activity. These andother studies revealed that LA appears to be an allosteric type enzyme exhibiting positive homotropism with respect to substrate and heterotropism with respect to the nucleotides tested.
The regulation of LA activity by high energy compounds, when coupled with asparagine synthetaseL suggests a relationship between amide synthesis-amide degradation and the energy levels of the cell.

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vii, 56 p. : ill.

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UNT Theses and Dissertations

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  • May 1979

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  • June 24, 2015, 9:39 a.m.

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  • Aug. 10, 2016, 10:20 p.m.

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Nalepka, Edward R. Studies of L-Asparaginase from Lactobacillus Plantarum, thesis, May 1979; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc663296/: accessed June 18, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; .