Denaturation, Renaturation and Other Structural Studies on Phosphoglucose Isomerases Page: 2
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transfer in which the proton is directly abstracted from
the alpha carbon (e.g., C-1) and transferred to a nucleo-
phile in the active center of the enzyme. Subsequently,
the same proton is transferred back to the accepting car-
banion (e.g., C-2).
Data from several other laboratories (Dorrer et al.,
1966; Fedtke, 1968; Gonzales de Galdeano and Simon, 1970;
Simon et al., 1964; Simon et al., 1968) clearly show that
the glucose 6-phosphate isomerase reaction proceeds both by
intramolecular and intermolecular proton migration and that
at 250C, the proton is transferred directly in more than half
of the catalytic turnovers.
Rose (1961) suggested that this was the result of a
higher activation energy for the exchange reaction compared
with the intramolecular transfer reaction, thus favoring
direct transfer at lower temperatures.
H k +
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Young, Clint D. Denaturation, Renaturation and Other Structural Studies on Phosphoglucose Isomerases, thesis, December 1975; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc663054/m1/4/: accessed September 25, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .