The importance of age and smoking in evaluating adverse cytogenetic effects of exposure to environmental agents

PDF Version Also Available for Download.

Description

Fluorescence in situ hybridization with chromosome-specific composite DNA probes (``chromosome painting``) is a reliable and efficient method for detecting structural chromosome aberrations. Painting is now being used to quantify chromosome damage in many human populations. In one such study we evaluated 91 unexposed people ranging in age from birth (cord bloods) to 79. We established a baseline frequency of stable aberrations that showed a highly significant curvi-linear increase with age (p < 0.00001) that accounted for 70% of the variance between donors. The magnitude of this effect illustrates the importance of understanding the cytogenetic changes that occur with age, which ... continued below

Physical Description

24 p.

Creation Information

Tucker, J.D. & Moore, D.H. II August 1, 1995.

Context

This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Authors

  • Tucker, J.D. Lawrence Livermore National Lab., CA (United States)
  • Moore, D.H. II California Pacific Medical Center, San Francisco, CA (United States). Cancer Research Institute

Sponsors

Publisher

Provided By

UNT Libraries Government Documents Department

Serving as both a federal and a state depository library, the UNT Libraries Government Documents Department maintains millions of items in a variety of formats. The department is a member of the FDLP Content Partnerships Program and an Affiliated Archive of the National Archives.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Description

Fluorescence in situ hybridization with chromosome-specific composite DNA probes (``chromosome painting``) is a reliable and efficient method for detecting structural chromosome aberrations. Painting is now being used to quantify chromosome damage in many human populations. In one such study we evaluated 91 unexposed people ranging in age from birth (cord bloods) to 79. We established a baseline frequency of stable aberrations that showed a highly significant curvi-linear increase with age (p < 0.00001) that accounted for 70% of the variance between donors. The magnitude of this effect illustrates the importance of understanding the cytogenetic changes that occur with age, which is particularly important for quantifying the effects of prior adverse environmental, occupational, or accidental exposure. In this paper we use the data obtained in our previous study to characterize the distribution of stable aberrations by age and pack-years of cigarette smoking. We also provide estimates of the number of cell equivalents that need to be scored to detect a given increase in aberrations above the background level surveyed in this population.

Physical Description

24 p.

Notes

OSTI as DE96002569

Source

  • 2. international conference on environmental mutagens in human populations, Prague (Czech Republic), 20-25 Aug 1995

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

  • Other: DE96002569
  • Report No.: UCRL-JC--121953
  • Report No.: CONF-950879--1
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 159352
  • Archival Resource Key: ark:/67531/metadc628018

Collections

This article is part of the following collection of related materials.

Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Creation Date

  • August 1, 1995

Added to The UNT Digital Library

  • June 16, 2015, 7:43 a.m.

Description Last Updated

  • Oct. 4, 2017, 2:07 p.m.

Usage Statistics

When was this article last used?

Yesterday: 0
Past 30 days: 0
Total Uses: 1

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Tucker, J.D. & Moore, D.H. II. The importance of age and smoking in evaluating adverse cytogenetic effects of exposure to environmental agents, article, August 1, 1995; California. (digital.library.unt.edu/ark:/67531/metadc628018/: accessed December 14, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.