Solution structure of detergent micelles at conditions relevant to membrane protein crystallization.

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Description

In this study small angle neutron scattering was used to characterize the formation of micelles in aqueous solutions of the detergents DMG and SPC as a function of detergent concentration and ionic strength of the solvent. The effects on the micelle structure of the additives glycerol and PEG, alone as well as in combination typical for actual membrane protein crystallization, were also explored. This research suggests that the micelles are cigar-like in form at the concentrations studied. The size of the micelles was observed to increase with increasing ionic strength but decrease with the addition of glycerol or PEG.

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21 p.

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Littrell, K.; Thiyagarajan, P.; Tiede, D. & Urban, V. July 2, 1999.

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This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 14 times . More information about this article can be viewed below.

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Description

In this study small angle neutron scattering was used to characterize the formation of micelles in aqueous solutions of the detergents DMG and SPC as a function of detergent concentration and ionic strength of the solvent. The effects on the micelle structure of the additives glycerol and PEG, alone as well as in combination typical for actual membrane protein crystallization, were also explored. This research suggests that the micelles are cigar-like in form at the concentrations studied. The size of the micelles was observed to increase with increasing ionic strength but decrease with the addition of glycerol or PEG.

Physical Description

21 p.

Notes

OSTI as DE00011879

Medium: P; Size: 21 pages

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  • 11th International Conference on Small-Angle Scattering (SAS '99), Upton, NY (US), 05/17/1999--05/20/1999

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  • Report No.: ANL/IPNS/CP-99414
  • Grant Number: W-31109-ENG-38
  • Office of Scientific & Technical Information Report Number: 11879
  • Archival Resource Key: ark:/67531/metadc627365

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  • July 2, 1999

Added to The UNT Digital Library

  • June 16, 2015, 7:43 a.m.

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  • April 7, 2017, 7:26 p.m.

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Littrell, K.; Thiyagarajan, P.; Tiede, D. & Urban, V. Solution structure of detergent micelles at conditions relevant to membrane protein crystallization., article, July 2, 1999; Illinois. (digital.library.unt.edu/ark:/67531/metadc627365/: accessed September 26, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.