Chromosome translocations measured by fluorescence in-situ hybridization: A promising biomarker

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Description

A biomarker for exposure and risk assessment would be most useful if it employs an endpoint that is highly quantitative, is stable with time, and is relevant to human risk. Recent advances in chromosome staining using fluorescence in situ hybridization (FISH) facilitate fast and reliable measurement of reciprocal translocations, a kind of DNA damage linked to both prior exposure and risk. In contrast to other biomarkers available, the frequency of reciprocal translocations in individuals exposed to whole-body radiation is stable with time post exposure, has a rather small inter-individual variability, and can be measured accurately at the low levels. Here, ... continued below

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13 p.

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Lucas, J.N. & Straume, T. October 1, 1995.

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Description

A biomarker for exposure and risk assessment would be most useful if it employs an endpoint that is highly quantitative, is stable with time, and is relevant to human risk. Recent advances in chromosome staining using fluorescence in situ hybridization (FISH) facilitate fast and reliable measurement of reciprocal translocations, a kind of DNA damage linked to both prior exposure and risk. In contrast to other biomarkers available, the frequency of reciprocal translocations in individuals exposed to whole-body radiation is stable with time post exposure, has a rather small inter-individual variability, and can be measured accurately at the low levels. Here, the authors discuss results from their studies demonstrating that chromosome painting can be used to reconstruct radiation dose for workers exposed within the dose limits, for individuals exposed a long time ago, and even for those who have been diagnosed with leukemia but not yet undergone therapy.

Physical Description

13 p.

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INIS; OSTI as DE96002123

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  • 5. Environmental toxicology and risk assessment: biomarkers and risk assessment, Denver, CO (United States), 2-7 Apr 1995

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  • Other: DE96002123
  • Report No.: UCRL-JC--122206
  • Report No.: CONF-9504216--1
  • Grant Number: W-7405-ENG-48
  • DOI: 10.2172/132690 | External Link
  • Office of Scientific & Technical Information Report Number: 132690
  • Archival Resource Key: ark:/67531/metadc625834

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • October 1, 1995

Added to The UNT Digital Library

  • June 16, 2015, 7:43 a.m.

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  • Feb. 23, 2016, 1:17 p.m.

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Lucas, J.N. & Straume, T. Chromosome translocations measured by fluorescence in-situ hybridization: A promising biomarker, report, October 1, 1995; California. (digital.library.unt.edu/ark:/67531/metadc625834/: accessed December 17, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.