Calculating survival curves in spread-peaks of heavy ion beams and comparison with experiment

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In preparing for treating patients with high-energy ion beams, it is important first to determine the composition of the beam, that is, the relative mixes of the various primary and secondary particles and their LET spectra, and secondly to estimate the cell killing expected during a treatment schedule. This requires measurements of the beam composition at various depths through the spread-peak region, and a calculation of cell survival using a cell-killing model designed to accommodate the mixed LET nature of the beam in the spread-peak region. This talk presents results of an experiment in which a particle identification telescope, the ... continued below

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4 p.

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Curtis, S.B.; Chu, W.T.; Llacer, J.; Renner, T.R.; Rodriguez, A. & Yang, T.C.H. August 1, 1995.

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In preparing for treating patients with high-energy ion beams, it is important first to determine the composition of the beam, that is, the relative mixes of the various primary and secondary particles and their LET spectra, and secondly to estimate the cell killing expected during a treatment schedule. This requires measurements of the beam composition at various depths through the spread-peak region, and a calculation of cell survival using a cell-killing model designed to accommodate the mixed LET nature of the beam in the spread-peak region. This talk presents results of an experiment in which a particle identification telescope, the BEPKLET, was used to measure the LET spectra of the primary and secondary particles at two positions in a 12-cm-spread-peak of a 585 MeV/amu neon ion beam at the Bevalac. Cell survival measurements were made at the same positions at which the LET-spectra were measured. The survival curves obtained were compared with calculations using the LPL (Lethal, Potentially Lethal) model of cell-killing. Results agree quite well at doses up to about 4 Gy. A quantity proportional to the RBE at 10% survival, when plotted against dose-averaged LET for a number of different beams and energies, appears to be a fairly good predictor of biological effect. This would not be expected if the difference in biological effect due to differences in track structure between various ions at the same LET played a significant role in modifying cell-killing in the range of LETs covered by this experiment.

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4 p.

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INIS; OSTI as DE96002282

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  • 5. workshop on heavy charged particles in biology and medicine, Darmstadt (Germany), 23-25 Aug 1995

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  • Other: DE96002282
  • Report No.: LBL--37655
  • Report No.: CONF-950871--1
  • Grant Number: AC03-76SF00098
  • Office of Scientific & Technical Information Report Number: 132738
  • Archival Resource Key: ark:/67531/metadc625807

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • August 1, 1995

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  • June 16, 2015, 7:43 a.m.

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  • April 5, 2016, 11:28 a.m.

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Curtis, S.B.; Chu, W.T.; Llacer, J.; Renner, T.R.; Rodriguez, A. & Yang, T.C.H. Calculating survival curves in spread-peaks of heavy ion beams and comparison with experiment, article, August 1, 1995; California. (digital.library.unt.edu/ark:/67531/metadc625807/: accessed December 14, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.