Biochemical studies relating to the effects of radiation and metals

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Various biochemical effects of radiation have been studied in 10 patients given total body x-ray in total doses of 75 to 310 r (skin), in 5 patients given 20 to 36 mc. P{sup 32}, and in 5 project personnel accidentally exposed to excessive doses of external radiations. Similar studies have also been made of several hundred Plutonium Project personnel exposed in most instances to relatively small amounts of uranium, lead and other metals, and to chemicals and radioactive sources. These studies included the investigation of liver function, of white blood cell chemistry, and of various urinary constituents such as coproporphyrin, ... continued below

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61 p.

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Schwartz, S. July 1, 1947.

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Description

Various biochemical effects of radiation have been studied in 10 patients given total body x-ray in total doses of 75 to 310 r (skin), in 5 patients given 20 to 36 mc. P{sup 32}, and in 5 project personnel accidentally exposed to excessive doses of external radiations. Similar studies have also been made of several hundred Plutonium Project personnel exposed in most instances to relatively small amounts of uranium, lead and other metals, and to chemicals and radioactive sources. These studies included the investigation of liver function, of white blood cell chemistry, and of various urinary constituents such as coproporphyrin, urorosein and other pigments, urobilinogen, ``corticosteroid-like`` substances, catalase, and uranium. Definitely excessive exposures resulted in various abnormalities in the above tests. With the exception of urinary uranium analysis none of them are specific in indicating overexposure to either radiation, metals, or chemicals. When interpreted in the light of the exposure and medical history, however, it is felt that they may aid in the clinical interpretation of relatively marked overexposure at least. In addition, they may afford further insight into the nature of radiation effects. The literature on the biochemical effects of radiation is reviewed briefly, and certain suggestions are offered regarding future investigations in this field.

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61 p.

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OSTI as DE95013603

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  • Other Information: PBD: 1 Jul 1947

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  • Other: DE95013603
  • Report No.: CH--3820
  • Grant Number: W-31-109-ENG-38
  • DOI: 10.2172/128984 | External Link
  • Office of Scientific & Technical Information Report Number: 128984
  • Archival Resource Key: ark:/67531/metadc623804

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • July 1, 1947

Added to The UNT Digital Library

  • June 16, 2015, 7:43 a.m.

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  • Dec. 15, 2015, 6:15 p.m.

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Schwartz, S. Biochemical studies relating to the effects of radiation and metals, report, July 1, 1947; Illinois. (digital.library.unt.edu/ark:/67531/metadc623804/: accessed June 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.