Possible uses of animal databases for further statistical evaluation and modeling

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Many studies have been performed in animals which mimic potential exposures of people in order to understand how factors modify radiation dose-response relationships. Cooperative analyses by investigators in different laboratories have a large potential for strengthening the conclusions that can be drawn from individual studies. When information on each animal is combined, then formal tests can be made to demonstrate that apparent consistencies or inconsistencies are statistically significant. Statistical methods must be carefully chosen so that differences between laboratories or studies can be controlled or described as part of the analysis in the interpretation of the conclusions. In this report, ... continued below

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4 p.

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Griffith, W.C.; Boecker, B.B.; Watson, C.R. & Gerber, G.B. October 1, 1995.

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  • Griffith, W.C.
  • Boecker, B.B. Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
  • Watson, C.R. Pacific Northwest Lab., Richland, WA (United States)
  • Gerber, G.B. European late Effects Project Group, Mol (Belgium)

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Description

Many studies have been performed in animals which mimic potential exposures of people in order to understand how factors modify radiation dose-response relationships. Cooperative analyses by investigators in different laboratories have a large potential for strengthening the conclusions that can be drawn from individual studies. When information on each animal is combined, then formal tests can be made to demonstrate that apparent consistencies or inconsistencies are statistically significant. Statistical methods must be carefully chosen so that differences between laboratories or studies can be controlled or described as part of the analysis in the interpretation of the conclusions. In this report, the example of bone cancer of the large number of studies of modifying factors for bone cancer available from studies in US and European laboratories.

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4 p.

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INIS; OSTI as DE96000325

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  • 10. international congress of radiation research (ICRR), Wurzburg (Germany), 27 Aug - 1 Sep 1995

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  • Other: DE96000325
  • Report No.: CONF-9508176--1
  • Grant Number: AC04-76EV01013
  • Office of Scientific & Technical Information Report Number: 115657
  • Archival Resource Key: ark:/67531/metadc623337

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  • October 1, 1995

Added to The UNT Digital Library

  • June 16, 2015, 7:43 a.m.

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  • Dec. 3, 2015, 6:04 p.m.

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Griffith, W.C.; Boecker, B.B.; Watson, C.R. & Gerber, G.B. Possible uses of animal databases for further statistical evaluation and modeling, article, October 1, 1995; United States. (digital.library.unt.edu/ark:/67531/metadc623337/: accessed September 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.