Effect of negative pions on the proliferative capacity of ascites tumor cells (lymphoma) grown in vivo Metadata

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  • Main Title Effect of negative pions on the proliferative capacity of ascites tumor cells (lymphoma) grown in vivo


  • Author: Feola, J.M.
    Creator Type: Personal
  • Author: Richman, C.
    Creator Type: Personal
  • Author: Raju, M.R.
    Creator Type: Personal
  • Author: Curtis, S.B.
    Creator Type: Personal
  • Author: Lawrence, J.H.
    Creator Type: Personal


  • Sponsor: United States. Department of Energy.
    Contributor Type: Organization
    Contributor Info: USDOE, Washington, DC (United States)


  • Name: Lawrence Livermore National Laboratory
    Place of Publication: California
    Additional Info: Lawrence Livermore National Lab., CA (United States)


  • Creation: 1967-03-30


  • English


  • Content Description: We have attempted to determine the relative biological effectiveness (RBE) of negative pions in the Bragg-peak region as compared to the plateau region and to gamma rays. We irradiated LAF{sub 1} mice, bearing 5-day-old lymphoma ascites tumors, in the peak and plateau regions of a 90-MeV pion beam for 40 hours in temperature-controlled holders. The animals were then sacrificed; lymphoma cells were withdrawn and titrated into adult female LAF{sub 1} mice. The proliferative capacity of the irradiated tumor cells was evaluated after 8 weeks by observing the percentage of animals developing ascites tumors. Surviving fractions were then calculated from LD{sub 50}`s of control and irradiated animals. Radiation doses in the 50 plateau region were measured with LiF dosimeters calibrated against cobalt-60 gamma rays. We calculated peak doses from those at the plateau, using a measured average peak-to-plateau ionization ratio of 1.5. Doses in the plateau region ranged from 145 to 250 rads; doses in the peak region ranged from 220 to 380 rads. The survival curve for cells irradiated in the peak region gave a D{sub 0} of 65 {plus_minus} 15 rads. The plateau points were not reliable. A replicate experiment was performed using Co{sup 60} {gamma}-rays, yielding a survival-curve D{sub 0} of 350 {plus_minus} 50 rads. If the {gamma}-ray D{sub 0} is taken as a baseline, an RBE of 5.4 {plus_minus} 1.8 is obtained for negative pions in the peak region, based on the ratio of-peak-region D{sub 0} to Co{sup 60} D{sub 0}.
  • Physical Description: 23 p.


  • Keyword: Lymphomas
  • Keyword: Experimental Neoplasms
  • Keyword: Mice
  • Keyword: Radiotherapy
  • STI Subject Categories: 55 Biology And Medicine, Basic Studies
  • Keyword: Pions Minus
  • Keyword: Radiation Doses
  • Keyword: Survival Curves
  • STI Subject Categories: 56 Biology And Medicine, Applied Studies
  • Keyword: Rbe


  • Other Information: PBD: 30 Mar 1967


  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI


  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report


  • Text


  • Other: DE95013615
  • Report No.: UCRL--17478
  • DOI: 10.2172/159358
  • Office of Scientific & Technical Information Report Number: 159358
  • Archival Resource Key: ark:/67531/metadc623285


  • Display Note: OSTI as DE95013615