Effect of negative pions on the proliferative capacity of ascites tumor cells (lymphoma) grown in vivo

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We have attempted to determine the relative biological effectiveness (RBE) of negative pions in the Bragg-peak region as compared to the plateau region and to gamma rays. We irradiated LAF{sub 1} mice, bearing 5-day-old lymphoma ascites tumors, in the peak and plateau regions of a 90-MeV pion beam for 40 hours in temperature-controlled holders. The animals were then sacrificed; lymphoma cells were withdrawn and titrated into adult female LAF{sub 1} mice. The proliferative capacity of the irradiated tumor cells was evaluated after 8 weeks by observing the percentage of animals developing ascites tumors. Surviving fractions were then calculated from LD{sub ... continued below

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23 p.

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Feola, J.M.; Richman, C.; Raju, M.R.; Curtis, S.B. & Lawrence, J.H. March 30, 1967.

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We have attempted to determine the relative biological effectiveness (RBE) of negative pions in the Bragg-peak region as compared to the plateau region and to gamma rays. We irradiated LAF{sub 1} mice, bearing 5-day-old lymphoma ascites tumors, in the peak and plateau regions of a 90-MeV pion beam for 40 hours in temperature-controlled holders. The animals were then sacrificed; lymphoma cells were withdrawn and titrated into adult female LAF{sub 1} mice. The proliferative capacity of the irradiated tumor cells was evaluated after 8 weeks by observing the percentage of animals developing ascites tumors. Surviving fractions were then calculated from LD{sub 50}`s of control and irradiated animals. Radiation doses in the 50 plateau region were measured with LiF dosimeters calibrated against cobalt-60 gamma rays. We calculated peak doses from those at the plateau, using a measured average peak-to-plateau ionization ratio of 1.5. Doses in the plateau region ranged from 145 to 250 rads; doses in the peak region ranged from 220 to 380 rads. The survival curve for cells irradiated in the peak region gave a D{sub 0} of 65 {plus_minus} 15 rads. The plateau points were not reliable. A replicate experiment was performed using Co{sup 60} {gamma}-rays, yielding a survival-curve D{sub 0} of 350 {plus_minus} 50 rads. If the {gamma}-ray D{sub 0} is taken as a baseline, an RBE of 5.4 {plus_minus} 1.8 is obtained for negative pions in the peak region, based on the ratio of-peak-region D{sub 0} to Co{sup 60} D{sub 0}.

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23 p.

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OSTI as DE95013615

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  • Other Information: PBD: 30 Mar 1967

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  • Other: DE95013615
  • Report No.: UCRL--17478
  • DOI: 10.2172/159358 | External Link
  • Office of Scientific & Technical Information Report Number: 159358
  • Archival Resource Key: ark:/67531/metadc623285

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  • March 30, 1967

Added to The UNT Digital Library

  • June 16, 2015, 7:43 a.m.

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  • Feb. 16, 2016, 6:35 p.m.

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Feola, J.M.; Richman, C.; Raju, M.R.; Curtis, S.B. & Lawrence, J.H. Effect of negative pions on the proliferative capacity of ascites tumor cells (lymphoma) grown in vivo, report, March 30, 1967; California. (digital.library.unt.edu/ark:/67531/metadc623285/: accessed October 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.