The structure of the muscle protein complex 4Ca{sup 2+}. Tronponin C*troponin: A Monte Carlo modeling analysis of small-angle X-ray and neutron scattering data

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Analysis of scattering data based on a Monte Carlo integration method was used to obtain a low resolution model of the 4Ca2+.troponin c.troponin I complex. This modeling method allows rapid testing of plausible structures where the best fit model can be ascertained by a comparison between model structure scattering profiles and measured scattering data. In the best fit model, troponin I appears as a spiral structure that wraps about 4CA2+.trophonin C which adopts an extended dumbell conformation similar to that observed in the crystal structures of troponin C. The Monte Carlo modeling method can be applied to other biological systems ... continued below

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18 p.

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Olah, G.A. & Trewhella, J. November 1, 1995.

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Analysis of scattering data based on a Monte Carlo integration method was used to obtain a low resolution model of the 4Ca2+.troponin c.troponin I complex. This modeling method allows rapid testing of plausible structures where the best fit model can be ascertained by a comparison between model structure scattering profiles and measured scattering data. In the best fit model, troponin I appears as a spiral structure that wraps about 4CA2+.trophonin C which adopts an extended dumbell conformation similar to that observed in the crystal structures of troponin C. The Monte Carlo modeling method can be applied to other biological systems in which detailed structural information is lacking.

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18 p.

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INIS; OSTI as DE96001839

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  • Neutrons in biology, Santa Fe, NM (United States), 24-28 Oct 1995

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  • Other: DE96001839
  • Report No.: LA-UR--95-3248
  • Report No.: CONF-9510226--1
  • Grant Number: W-7405-ENG-36
  • Office of Scientific & Technical Information Report Number: 120856
  • Archival Resource Key: ark:/67531/metadc622492

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  • November 1, 1995

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  • June 16, 2015, 7:43 a.m.

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  • Oct. 4, 2017, 2:07 p.m.

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Olah, G.A. & Trewhella, J. The structure of the muscle protein complex 4Ca{sup 2+}. Tronponin C*troponin: A Monte Carlo modeling analysis of small-angle X-ray and neutron scattering data, article, November 1, 1995; New Mexico. (digital.library.unt.edu/ark:/67531/metadc622492/: accessed December 17, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.