Blood changes in humans following total body irradiation

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Description

A major problem encountered in the Manhattan Project was the protection of workers against damage resulting from acute or chronic exposure to external radiation. The problem of how to detect evidence of damage following exposure to total body radiation led to this study. These studies were conducted between January, 1942 and November, 1945. Three groups of persons were employed in this study. The first group of eight individuals harboring incurable neoplasms which was not extensive enough to influence general health, these patients were treated with 400 KV x-radiation while sitting in a wooden chair, doses were 27, 60, and 120r. ... continued below

Physical Description

65 p.

Creation Information

Cantril, S.T.; Jacobson, L.O.; Schwartz, S. & Nickson, J.J. June 2, 1947.

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Description

A major problem encountered in the Manhattan Project was the protection of workers against damage resulting from acute or chronic exposure to external radiation. The problem of how to detect evidence of damage following exposure to total body radiation led to this study. These studies were conducted between January, 1942 and November, 1945. Three groups of persons were employed in this study. The first group of eight individuals harboring incurable neoplasms which was not extensive enough to influence general health, these patients were treated with 400 KV x-radiation while sitting in a wooden chair, doses were 27, 60, and 120r. Three persons having generalized illnesses chronic in nature were given total body radiation using 200 KV X-rays in multiple exposures totaling 100, 300, and 500r. A third group of normal volunteers from personnel of the Metallurgical Laboratory were treated with 200 KV x-rays in three divided doses totaling 21 r. Changes in peripheral blood in the fourteen individuals is reported. In group 1 the most persistent abnormality noted was a diminution in the number of lymphocytes after completion of the treatment. In group 2 a depression in the lymphocytes was also the most marked single change. In group 3 no alterations in peripheral blood was observed.

Physical Description

65 p.

Notes

OSTI as DE95013635

Source

  • Other Information: PBD: 2 Jun 1947

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  • Other: DE95013635
  • Report No.: AECD--2432
  • Report No.: CH--3868
  • DOI: 10.2172/122041 | External Link
  • Office of Scientific & Technical Information Report Number: 122041
  • Archival Resource Key: ark:/67531/metadc620401

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • June 2, 1947

Added to The UNT Digital Library

  • June 16, 2015, 7:43 a.m.

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Cantril, S.T.; Jacobson, L.O.; Schwartz, S. & Nickson, J.J. Blood changes in humans following total body irradiation, report, June 2, 1947; United States. (digital.library.unt.edu/ark:/67531/metadc620401/: accessed November 25, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.