In vivo argon laser vascular welding using thermal feedback: open and closed loop patency and collagen crosslinking

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An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 {micro}m optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated ... continued below

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8 pages; Other: FDE: PDF

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Small, W., LLNL February 28, 1997.

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Description

An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 {micro}m optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated either visually (leak/no leak) or by in vivo burst pressure measurements. Biochemical assays were performed to investigate the possible laser-induced formation or destruction of enzymatically mediated covalent crosslinks between collagen molecules. Viable welds were created both with and without the use of feedback control. Tissues maintained at 50 C using feedback control had an elevated crosslink count compared to controls, while those irradiated without feedback control experienced a decrease. Differences between the volumetric heating associated with open and closed loop protocols may account for the different effects on collagen crosslinks. Covalent mechanisms may play a role in argon laser vascular fusion.

Physical Description

8 pages; Other: FDE: PDF

Notes

OSTI as DE00016370

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  • Conference title not supplied, Conference location not supplied, Conference dates not supplied; Other Information: Supercedes report DE98050988; PBD: 28 Feb 97

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  • Other: DE98050988
  • Report No.: UCRL-JC-126839
  • Report No.: CONF-970231*--
  • Grant Number: W-7405-Eng-48
  • Office of Scientific & Technical Information Report Number: 16370
  • Archival Resource Key: ark:/67531/metadc619182

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • February 28, 1997

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  • June 16, 2015, 7:43 a.m.

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  • Jan. 3, 2017, 4:40 p.m.

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Small, W., LLNL. In vivo argon laser vascular welding using thermal feedback: open and closed loop patency and collagen crosslinking, article, February 28, 1997; (digital.library.unt.edu/ark:/67531/metadc619182/: accessed January 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.