Chemical Literature, Volume 4, Number 1, Spring 1952 Page: 4
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DIVISION OF CHEMICAL LITERATURE
AMERICAN CHEMICAL SOCIETY
Abstracts of Papers to be Presented at
Buffalo, New York, March 24-26, 1952
Julian F. Smith, Chairman
CIIHMICAL-BIOLOGICAL CLEARING IOUSES
(Joint with the Division of Biological Chemistry)
W. H. Longenecker, Presiding
2:00- 1. Introductory Remarks. W. H. LONGENECKER,
E.I. du Pont de Nemours and Company, Inc., Wilmington,
2:10- 2. The Parke, Davis Central Records Office: Its
Organization and Operation. LEONORE R.
SCHROEDER, Parke, Davis Research Laboratories,
A chemical-biological clearing house was set up at the Parke,
Davis Research Laboratories early in 1947 to fill a recognized
need for the centralization of research data, related records,
and experimental samples. Whereas previously, each research
group had been responsible for its own individual files and
records, some more nearly complete than others, the Central
Records Office was assigned the task of bringing together
all such data into one central file to which all groups would
have ready access.
To this end, four initial files were established: a drug file,
6"x10" cards carrying detailed chemical, physical, and pharmacological
data on the individual compounds studied in our
research screening program; and three auxiliary files serving
principally as indexes to the drug file - one by Chemical
A bstracts name, another by molecular formula, and a third
by chemical structure. The latter is an adaptation of the Wiselogle
Classification System to 6/2"x7Y2" McBee Keysort Cards.
From the manipulation of these files, Central Records Office
responsibility has gradually expanded to include such related
functions as the preparation of test protocol forms, the reproduction
and circulation of a monthly summary of all screening:
results, and the preparation of periodic reports to all persons
outside the laboratories who provide compounds for screening
The organization and present operation of the office will be
discussed in detail.
2:35- 3. Reporting and Indexing Biological Data By IBM
Punched Card Methods. E.E. DUNN and G.E. LYNN,
Biochemical Research Department, The Dow
Chemical Company, Midland, Michigan.
Punched cards are being used to provide for the accumulation
of large volumes of data in readily available form, to provide
adequate cross-indexing, and to permit rapid duplication for
distribution. Indexing is obtained by numerical coding for
individual chemical compound, chemical structure type, test
organism, and test method.
The data are received and transferred to punched cards by a
central tabulating division. From these cards there are distributed
multiple copies of printed lists giving name of chemical,
scientific name of test organism, abbreviation of words
describing biological effects, control or mortality figures when
obtained, test method, and year data where obtained.
Sorting.and listing of data can be done readily on the basis
of any item numerically coded, and to a limited extent on
Charlotte S. Schaler, Secretary
3:00- 4. The Recording and Interpretation of Chemical
Biological Data at the Rohm and Haas Co. J. 0
VAN HOOK, Rohm and Haas Co., Philadelphia, p,
A practical day-to-day description of the recording and inter
pretation of insecticidal, arachnicidal, fungicidal, and herb
cidal data as carried out by the Rohm and Haas Co. is presented.
This includes the following: (1) Compounds from various
sources are given a code number by the synthetic laboratory,
filed according to empirical formula, and then transmitted t
the evaluation laboratories. (2) The pesticidal data obtaine:
by the testing laboratories are recorded on master sheets
which are filed in the testing laboratory, the synthetic labor.
tory, and the administrative offices. (3) All data are trans.
ferred to special McBee punch cards by the synthetic labor.
tory. These cards are punched according to chemical structure,
empirical formula, and performance data. (4) All data wre
discussed in conference by interested parties, and recommends.
tions for further evaluation and also future synthetic work at
made and recorded on the master sheets. (5) Periodical,
reports are written correlating performance data with chernmice
3:25- 5. Centralization and Control of Chemical and Biological
Data. HAROLD A. CLYMER And MASON
FERNALD, Smith, Kline and French Laboratories,
In an industrial research organization, the need for some mech
anism of accumulating and classifying scientific data from
diverse sources so that they are readily available for futtut
reference is a recognized problem. The approach must be go0
erned by the specific requirements of the industry concerned
and by justifiable expenditures.
For a pharmaceutical research laboratory dealing primcri1
with physical, chemical, and biological data, there are twC
essential considerations: first, the establishment of a centrmc
agency to receive and distribute compounds for testing, andtc,
collect and classify the resulting data; and second, the eo'
ployment by this agercy of simple systems for recording c
indexing these data. The keystone of the latter phase entais
development of a specially designed master data card (Keys5
punch type) which facilitates selection or grouping of datac
compounds according to source, chemical structure, and/ortyp
of biological activity.
3:50- 6. Coordination and Integration at Sterling-WinthroP
Research Institute. OLIVER H. BUCHANAN,
Sterling-Winthrop Research' Institute, Rensselaer,
All chemical-biological clearing units have many problems b
common, but each has its own individual and distinct duties
and perplexities. The Section for Coordination and Integrati'
at Sterling-Winthrop Research Institute is a neophyte in thi
field, but serves not only as the usual chemical-biolog
clearing house but as the central coordinating and integrat~
unit for all research and technical activities carried out by
the Institute for the other 65 or so divisions and subsidiaries
of Sterling Drug Inc.
For purpose of coordination and integration, all activi1'e
of the Institute have been classified under a six-point rese i
category system as follows: (1) chemicalresearch and devel
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American Chemical Society. Division of Chemical Literature. Chemical Literature, Volume 4, Number 1, Spring 1952, periodical, Spring 1952; Philadelphia, Pennsylvania. (digital.library.unt.edu/ark:/67531/metadc5771/m1/4/: accessed November 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .