Chemical Literature, Volume 20, Number 2, Fall 1968 Page: 4
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AMERICAN CHEMICAL SOCIETY DIVISION OF
Joe Haller Clark, Chairman Margaret S. Hicks, Secretary
156th ACS National Meeting Abstracts Atlantic City, New Jersey
MONDAY MORNING & AFTERNOON - SYMPOSIUM ON TOXICOLOGICAL CENTERS - F. R. Benson, Presiding
1. THE AMERICAN MEDICAL ASSOCIATION REGISTRY ON ADVERSE REACTIONS. Norman De Nosaquo,
American Medical Association, Department of Drugs, 535 North Dearborn Street, Chicago,
The American Medical Association embarked on a program for the reporting of drug
induced blood dyscrasias in 1953, following the appearance of reports of aplastic anemia
associated with the use of chloramphenicol. In addition to the direct reports received
voluntarily from physicians and hospitals review of the world literature available to
the Registry was undertaken. As a result of this effort the Registry was expanded in
1960 to an overall Registry on Adverse Reactions. Eight consultative advisory panels
were established to assist the Registry in the fields of allergy, dermatology, gastroenterology,
hematology, nephrology, neurology and psychiatry, pediatrics, and household
and economic chemicals. In 1967 the Council on Drugs shifted the emphasis from adverse
reactions to a Drug Utilization Study to investigate the therapeutic use of drugs. A
primary objective of the A.M.A. is continuing medical education. This has been accomplished
by the Registry through such techniques as exhibits at medical meetings where
slides of examples of reactions are shown, and distribution of tabulations of direct
reports received, brochures, and articles dealing with drug-induced reactions. The
discussion will cover the effort at computerization of the data. Slides to illustrate
the type of information available through examination of the reports, and the program
for storage and retrieval of information will be shown.
2. INPUT, HANDLIING AND DISSEMINATION OF ADVERSE DRUG Ei:ECPIENCE AT FDA. Arthur Rskin,
Department of Health, Education, and Welfare, Food and Drug Administration MD- ,
200 C Street, S. W., Washington, D. C., 20204.
The Division of Drug Experience of the Office of Medical Support in the Bureau of
Medicine, FDA, deals with the development, input, output, and dissemination of adverse
drug experience. For this purpose the Collection and Evaluation Branch screens and
codes suspected adverse reactions received from over 100 hospitals, manufacturers (as
required by law), and individual physicians. After quality control the coded, evaluated
adverse events with their associated drugs are stored in the central IM 360/40 computer.
The Searches and Reports Branch is responsible for routine and special searches. This
branch edits the computer printouts and sends reactions of alert or special significance
to the various administrative and operating offices of the FDA. Committees of the above
branches develop new data base elements, codes, and dictionaries, in cooperation with
the separate Division of Data Processing, which operates the computer. Finally, the
Research and Development Branch develops new sources of adverse drug data, including
hospitals, university centers, and investigative programs. This branch also publishes
the FDA Reports of Suspected Adverse Reactions to Drugs. Our computerized data bank
now includes upward of 20,000 evaluated adverse drug events. It is a successfully
operating, rapidly expanding system. We are cooperating with the WHO Pilot Project on
Drug Monitoring located in Alexandria, Virginia, and engaged in setting up an early
warning system involving the U.S.A. and nine other countries.
3. INFORMATIOt FROM AND TO POISON CONTROL CENTERS, Henry L. Verhulst, Chief, Poison,
Control Branch, Division of Direct Health Services, Public Health Service, U.S.
Department of Health, Education, and Welfare, Silver Spring, Maryland 20910
The Poison Control Branch, U.S. Public Health Service, maintains a file of
information on product formulation and potential hazards of acute overdosage. This
is based on reports by the company of animal studies or which the Branch staff gleans
from the literature. The data then are condensed and supplied to the poison control
centers in a format which gives the physician information of the principle hazards
and recommended treatment. The poison control centers, in return, send to the Poison
Control Branch a report form giving details of the cases. Approximately 90,000
reports are received annually, 65,000 involving accidental ingestions by children
under five years of age. The rest involve accidental exposures among adults, or selfpoisoning.
Although many of these reports furnish valuable clinical material, there
are certain restrictions which must be considered in their evaluation. This paper
will discuss the program operation to provide a better understanding of the data
available from this unit.
4. INFORMATION ON HEALTH ASPECTS OF PESTICIDES. Philip C. Minter, Wayland J. Hayes,
Jr., Pesticides Program, National Communicable Disease Center, Atlanta, Ga. 30333
Over a period of 20 years, a collection of 17,000 references on the toxicology of
pesticides has been gathered by the Toxicology Section, Pesticides Program, National
Communicable Disease Center. These data have been recorded on hand sort cards. Approximately
6,000 of the 17,000 articles have been stored as reprints. The scope and
number of personnel in the Pesticides Program of the Public Health Service has been
greatly expanded in recent years, and over 400 persons are now employed by or are working
under contracts sponsored by the Program. The Pesticides Program has responsibility
for assisting State and local health departments in matters concerning pesticides, and
health officials need to be familiar with the literature concerning health aspects of
pesticides. To serve the needs of these persons and to meet the recommendations of various
committees that information on the toxicology of pesticides be disseminated, a
monthly bulletin containing abstracts of the worldwide literature pertaining to healthrelated
aspects of pesticides will be published. The abstracts will be obtained from
over 500 publications scanned regularly for items of interest. The bulletin, when published,
should be especially useful to medical researchers and chemists working on
pesticides; however, it is aimed at all workers involved in studies and programs relatinf
to the effects of pesticides on human health. The abstract bulletin will be availabIe
on subscription from the Superintendent of Documents of the Government Printing
Office. As a corollary to the Abstract Bulletin, a computer tape of references and
abstracts will be produced. In future years when the store of references has developed,
these tapes will be used to perform specialized searches.
5. AN OCCUPATIONAL HEALTH INFORMATION SERVICE. Dohrman H. Byers, National
Center for Urban and Industrial Health, Occupational Health Program, 1014 Broadway,
Cincinnati, Ohio 45202
The Scientific Reference Service (SRS) of the Occupational Health Program, National
Center for Urban and Industrial Health provides an information resource serving the
Program research and field personnel, State and other Federal agencies, industry, labor,
physicians, attorneys and the general public. Inquiries on any aspect of occupational health
are accepted by letter or telephone. The information resources of SRS and the expertise of
the professional staff of the Occupational Health Program are utilized to provide as complete
and factual replies as possible. Individual replies are prepared and reviewed by
occupational health specialists, thereby incorporating professional evaluation, judgment,
and opinion as appropriate to the inquiry. An information storage and retrieval system is
operational but still developing, utilizing a special thesaurus and index searching by the
optical coincidence technique. Approximately 1500 inquiries per year are being handled
at present. The bulk of these ask for information on toxicology of chemicals or productstolerance
limits, physiologic effects, and hazards to health.
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American Chemical Society. Division of Chemical Literature. Chemical Literature, Volume 20, Number 2, Fall 1968, periodical, Autumn 1968; Philadelphia, Pennsylvania. (digital.library.unt.edu/ark:/67531/metadc5712/m1/4/: accessed September 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .