Effect of Colchicine on Neuronal Excitabilty

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The abundance of microtubules in receptive dendrites suggests they may function in sensory transduction. Responses of frog muscle spindle receptors and joint receptors is inhibited within 25 minutes by 50 mM colchicine, a microtubuledisrupting agent. The inhibition is reversible upon removal of colchicine, and the time course of recovery is comparable to that of inhibition. Frog olfactory responses are briefly inhibited by washing the olfactory mucosa with perfusion fluid. Colchicine accentuates the inhibition and substantially retards the rate of recovery in a dose-dependent fashion. Colchicine does not affect axonal conduction, nor the oxygen uptake of isolated crab or frog leg ... continued below

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vi, 42 leaves : ill.

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Okafo, Ngozi August 1978.

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  • Okafo, Ngozi

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The abundance of microtubules in receptive dendrites suggests they may function in sensory transduction. Responses of frog muscle spindle receptors and joint receptors is inhibited within 25 minutes by 50 mM colchicine, a microtubuledisrupting agent. The inhibition is reversible upon removal of colchicine, and the time course of recovery is comparable to that of inhibition. Frog olfactory responses are briefly inhibited by washing the olfactory mucosa with perfusion fluid. Colchicine accentuates the inhibition and substantially retards the rate of recovery in a dose-dependent fashion. Colchicine does not affect axonal conduction, nor the oxygen uptake of isolated crab or frog leg nerves. The inhibitory action of colchicine is therefore an effect on the electrical excitability of the receptive dendrites or soma, and not an effect on axonal conduction.

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vi, 42 leaves : ill.

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UNT Theses and Dissertations

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  • August 1978

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  • May 10, 2015, 6:16 a.m.

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  • June 11, 2016, 1:08 p.m.

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Okafo, Ngozi. Effect of Colchicine on Neuronal Excitabilty, thesis, August 1978; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc504537/: accessed December 11, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .