Optimization of High Performance Liquid Chromatographic Separations

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This study had a twofold purpose. First, the usefulness of the simplex algorithm as a short method of optimization in high performance liquid chromatographic separations was investigated. The second was to test a modified simplex method. The volume fractions of mobile phase components were chosen as the variable factors in the optimization process. Four test cases were performed which included separation of cholesterol esters, naphthalene and its derivatives, polycyclic aromatic compounds, and the thiane compounds. The standard for accepting an optimum was based on the baseline separation of two adjacent peaks and the analysis time. In addition to successful separations, ... continued below

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ix, 111 leaves: ill.

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Nguyen, Khanh Thi August 1983.

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  • Nguyen, Khanh Thi

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This study had a twofold purpose. First, the usefulness of the simplex algorithm as a short method of optimization in high performance liquid chromatographic separations was investigated. The second was to test a modified simplex method. The volume fractions of mobile phase components were chosen as the variable factors in the optimization process. Four test cases were performed which included separation of cholesterol esters, naphthalene and its derivatives, polycyclic aromatic compounds, and the thiane compounds. The standard for accepting an optimum was based on the baseline separation of two adjacent peaks and the analysis time. In addition to successful separations, the correlation between the separation and the chemical characteristics of mobile phase compositions was calculated and this could then be used for further modification of simplex search strategy.

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ix, 111 leaves: ill.

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  • August 1983

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  • May 10, 2015, 6:16 a.m.

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  • Dec. 15, 2016, 9:43 a.m.

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Nguyen, Khanh Thi. Optimization of High Performance Liquid Chromatographic Separations, thesis, August 1983; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc504387/: accessed September 24, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .