Serotonin, Norepinephrine, and the Hypothalamic Ventromedial Nucleus: a Proposed Mechanism Mediating Hyperphagia and Obesity

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Serotonin has been implicated as a modulator of feeding behavior. This experiment was designed to alter brain serotonin levels through dietary means in hypothalamic ventromedial-lesioned and unlesioned rats. Daily food, water, and animal weights were measured. The purpose was to determine if VMH lesions altered the feeding pattern found in unlesioned rats. Although food intake for tryptophanenriched diets and tryptophan-deficient diets did not differ from their respective control groups, in some cases gross animal weights did differ significantly between experimental and control groups and between lesioned and unlesioned groups. A proposed model explains how a "low" energy signal and a ... continued below

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vii, 95 leaves: ill.

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McDermott, Kathy Howard May 1981.

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This thesis is part of the collection entitled: UNT Theses and Dissertations and was provided by UNT Libraries to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 93 times , with 15 in the last month . More information about this thesis can be viewed below.

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  • McDermott, Kathy Howard

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Serotonin has been implicated as a modulator of feeding behavior. This experiment was designed to alter brain serotonin levels through dietary means in hypothalamic ventromedial-lesioned and unlesioned rats. Daily food, water, and animal weights were measured. The purpose was to determine if VMH lesions altered the feeding pattern found in unlesioned rats. Although food intake for tryptophanenriched diets and tryptophan-deficient diets did not differ from their respective control groups, in some cases gross animal weights did differ significantly between experimental and control groups and between lesioned and unlesioned groups. A proposed model explains how a "low" energy signal and a "high" protein signal cycles amino acids through gluconeogenesis to comPensate for an energy deficit.

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vii, 95 leaves: ill.

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UNT Theses and Dissertations

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  • May 1981

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  • May 10, 2015, 6:16 a.m.

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  • Feb. 6, 2017, 11:11 a.m.

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McDermott, Kathy Howard. Serotonin, Norepinephrine, and the Hypothalamic Ventromedial Nucleus: a Proposed Mechanism Mediating Hyperphagia and Obesity, thesis, May 1981; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc504188/: accessed January 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .