Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison

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A rabbit keratoconjunctivities model was used to evaluate ophthalmic formulations containing 1 percent sodium cephalothin in silicon oil, a 1 percent sodium cephalothin aqueous solution, and a 0.3 percent gentamicin sulfate solution. Rabit eyes were inoculated intracorneally with Pseudomonas aeruginosa, Staphylococcus aureus, or Streptococcus pneumoniae, After topical treatment, none of the antibiotic formulations were effective in the P. aeruginosa model; all three showed good activity against S. aureus, and against S. pneumoniae, the caphalothin formulations were more effective than gentamicin.In a related stability study, the cephalothin potency of the silicon formulation was maintained for 16 weeks at 4, 25, and ... continued below

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v, 44 leaves : ill.

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Carney, Gerald R. August 1979.

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  • Carney, Gerald R.

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A rabbit keratoconjunctivities model was used to evaluate ophthalmic formulations containing 1 percent sodium cephalothin in silicon oil, a 1 percent sodium cephalothin aqueous solution, and a 0.3 percent gentamicin sulfate solution. Rabit eyes were inoculated intracorneally with Pseudomonas aeruginosa, Staphylococcus aureus, or Streptococcus pneumoniae, After topical treatment, none of the antibiotic formulations were effective in the P. aeruginosa model; all three showed good activity against S. aureus, and against S. pneumoniae, the caphalothin formulations were more effective than gentamicin.In a related stability study, the cephalothin potency of the silicon formulation was maintained for 16 weeks at 4, 25, and 450 C These studies suggest that sodium cephalothin can be formulated as an effective and stable ophthalmic dosage form.

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v, 44 leaves : ill.

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  • August 1979

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  • May 10, 2015, 6:16 a.m.

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  • June 9, 2016, 3:25 p.m.

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Carney, Gerald R. Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison, thesis, August 1979; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc504094/: accessed December 12, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .