Studies on the Biological Activity of N-nitrosamines

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Two aspects of the biological activity of N-nitrosamines were studied. First, the effect of ascorbate on the mutagenicity of N-nitrosopiperidines was studied in the Ames Salmanella/ mammalian microsome mutagenicity test. The addition of ascorbate significantly enhanced the mutagenicity of these compounds. This enhancement was selective for N-nitrosamines suggesting a possible role of ascorbate in N-nitrosamine induced carcinogenicity. Second, the technique of velocity sedimentation in alkaline sucrose density gradients was applied to the detection of N-nitrosamine induced DNA damage in Balb/c 3T3 cells. This technique detected N-nitrosamine induced DNA damage when the cells were made permeable before treatment. This technique compares ... continued below

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vi, 108 leaves: ill.

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Barton, Rodney A. (Rodney Alan) August 1980.

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  • Barton, Rodney A. (Rodney Alan)

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Two aspects of the biological activity of N-nitrosamines were studied. First, the effect of ascorbate on the mutagenicity of N-nitrosopiperidines was studied in the Ames Salmanella/ mammalian microsome mutagenicity test. The addition of ascorbate significantly enhanced the mutagenicity of these compounds. This enhancement was selective for N-nitrosamines suggesting a possible role of ascorbate in N-nitrosamine induced carcinogenicity. Second, the technique of velocity sedimentation in alkaline sucrose density gradients was applied to the detection of N-nitrosamine induced DNA damage in Balb/c 3T3 cells. This technique detected N-nitrosamine induced DNA damage when the cells were made permeable before treatment. This technique compares favorably with other test systems used to evaluate N-nitrosamines and should be useful in further studies of N-nitrosamines.

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vi, 108 leaves: ill.

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  • August 1980

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  • May 10, 2015, 6:16 a.m.

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  • Feb. 9, 2017, 10 a.m.

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Barton, Rodney A. (Rodney Alan). Studies on the Biological Activity of N-nitrosamines, thesis, August 1980; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc504066/: accessed July 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .