The Regulation of HMG-CoA Reductase by Enzyme-Lipid Interactions

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The temperature-dependent catalytic activity of rat liver 3-hydroxy-3 -methylglutaryl coenzyme A reductase (HMG-CoA reductase) displays the nonlinear Arrhenius behavior characteristic of many membrane-bound enzymes. A two-conformer equilibrium model has been developed to characterize this behavior. In the model, HMG-CoA reductase undergoes a conformational change from a low specific activity to a high specific activity form. This conformation change is apparently driven by a temperature-dependent phase transition of the membrane lipids. It has been found that this model accurately describes the data from diets including rat chow, low-fat, high-carbohydrate, and diets supplemented with fat, cholesterol or cholestyramine. The effects characterized by ... continued below

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iii, 84 leaves: ill.

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Smith, Vana L. May 1981.

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  • Smith, Vana L.

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The temperature-dependent catalytic activity of rat liver 3-hydroxy-3 -methylglutaryl coenzyme A reductase (HMG-CoA reductase) displays the nonlinear Arrhenius behavior characteristic of many membrane-bound enzymes. A two-conformer equilibrium model has been developed to characterize this behavior. In the model, HMG-CoA reductase undergoes a conformational change from a low specific activity to a high specific activity form. This conformation change is apparently driven by a temperature-dependent phase transition of the membrane lipids. It has been found that this model accurately describes the data from diets including rat chow, low-fat, high-carbohydrate, and diets supplemented with fat, cholesterol or cholestyramine. The effects characterized by the model are consistent with the regulation of HMG-CoA reductase by enzyme-lipid interactions.

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iii, 84 leaves: ill.

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  • May 1981

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  • May 10, 2015, 6:16 a.m.

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  • Jan. 30, 2017, 9:44 a.m.

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Smith, Vana L. The Regulation of HMG-CoA Reductase by Enzyme-Lipid Interactions, thesis, May 1981; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc504046/: accessed September 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .