Effect of Operant Behavior on the Metabolism of 5-Hydroxytryptamine

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The role of operant behavior in the metabolism of brain 5-hydroxytryptamine (5-HT) turnover was investigated. Two and one-half hours following the administration of 150 mg/kg of para-chlorophenylalanine (PCPA), a specific inhibitor of tryptophan hydroxylase, levels of 5-HT were compared in sedentary and performing rats. Whole brain levels of serotonin were reduced in both responding and sedentary animals; however, differences between these groups were not statistically significant. The drug induced decrease in 5-HT levels was accompanied by a significant decrease in session responding. The degree of suppressed responding could be correlated with the level of 5-HT following PCPA, suggesting that the ... continued below

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v, 87 leaves: ill.

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Shepard, Paul August 1979.

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  • Shepard, Paul

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The role of operant behavior in the metabolism of brain 5-hydroxytryptamine (5-HT) turnover was investigated. Two and one-half hours following the administration of 150 mg/kg of para-chlorophenylalanine (PCPA), a specific inhibitor of tryptophan hydroxylase, levels of 5-HT were compared in sedentary and performing rats. Whole brain levels of serotonin were reduced in both responding and sedentary animals; however, differences between these groups were not statistically significant. The drug induced decrease in 5-HT levels was accompanied by a significant decrease in session responding. The degree of suppressed responding could be correlated with the level of 5-HT following PCPA, suggesting that the metabolism of serotonin is in part modulated by the rate of responding as maintained by the operant schedule.

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v, 87 leaves: ill.

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UNT Theses and Dissertations

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  • August 1979

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  • May 10, 2015, 6:16 a.m.

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  • June 3, 2016, 11:06 a.m.

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Citations, Rights, Re-Use

Shepard, Paul. Effect of Operant Behavior on the Metabolism of 5-Hydroxytryptamine, thesis, August 1979; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc503958/: accessed December 17, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .