Ethylbromo Acetate as an Olfactory Probe

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Olfactory transduction mechanisms are best studied when specific blocking agents are available with which to modify cellular responses to odorant stimulation. This study is an electrophysiological investigation of functional group-specific olfactory acceptor mechanisms using ethylbromo acetate (EtBrAc), a World War I war gas which inhibits olfactory responses to odorant stimulation. The major findings of this investigation show that (1) vaporous EtBrAc is found to be a quick and effective inhibitor of electroolfactogram (EOG) responses to odorant stimulation, (2) isoamyl acetate is shown to protect EOG responses to a wide variety of odorants, inclusive of itself, from the inhibition effect of ... continued below

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vii, 75 leaves : ill.

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McClure, Fred Leland August 1980.

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  • McClure, Fred Leland

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Olfactory transduction mechanisms are best studied when specific blocking agents are available with which to modify cellular responses to odorant stimulation. This study is an electrophysiological investigation of functional group-specific olfactory acceptor mechanisms using ethylbromo acetate (EtBrAc), a World War I war gas which inhibits olfactory responses to odorant stimulation. The major findings of this investigation show that (1) vaporous EtBrAc is found to be a quick and effective inhibitor of electroolfactogram (EOG) responses to odorant stimulation, (2) isoamyl acetate is shown to protect EOG responses to a wide variety of odorants, inclusive of itself, from the inhibition effect of EtBrAc treatment, and (3) amine acceptor sites exist which are resistant to the inhibitory effects fo EtBrAc treatment.

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vii, 75 leaves : ill.

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UNT Theses and Dissertations

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  • August 1980

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  • May 10, 2015, 6:16 a.m.

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  • March 20, 2017, 3:46 p.m.

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McClure, Fred Leland. Ethylbromo Acetate as an Olfactory Probe, thesis, August 1980; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc503901/: accessed June 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .