Histochemical Characterization of Lymphocytes in Preleukemic and Leukemic AKR Mice

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The AKR strain of mice have a genetic trait for spontaneous development of lymphocytic leukemia. In this study, leukemic mice were found to have significantly larger (p<0.01) thymuses and spleens than preleukemic mice. The enlarged leukemic tissues were densely packed with a light staining cell, with a hollow-appearing nucleus. Tissues from preleukemic mice were observed to be infiltrated with a smaller, darker-staining lymphocyte. Fluorescent antibody staining was done on preleukemic and leukemic tissues, using three antisera against murine lymphocyte theta antigen, and an antiserum against murine IgG. Significantly brighter fluorescence, (p <0.05) with theta-specific antisera, was found in leukemic thymuses,spleens, ... continued below

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v, 117 leaves : ill.

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Michnoff, Carolyn A. May 1979.

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  • Michnoff, Carolyn A.

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The AKR strain of mice have a genetic trait for spontaneous development of lymphocytic leukemia. In this study, leukemic mice were found to have significantly larger (p<0.01) thymuses and spleens than preleukemic mice. The enlarged leukemic tissues were densely packed with a light staining cell, with a hollow-appearing nucleus. Tissues from preleukemic mice were observed to be infiltrated with a smaller, darker-staining lymphocyte. Fluorescent antibody staining was done on preleukemic and leukemic tissues, using three antisera against murine lymphocyte theta antigen, and an antiserum against murine IgG. Significantly brighter fluorescence, (p <0.05) with theta-specific antisera, was found in leukemic thymuses,spleens, and kidneys than in the same preleukemic tissues. Leukemic tissues had significantly brighter fluorescence (p <0.05) than preleukemic tissues with IgG antiserum.

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v, 117 leaves : ill.

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  • May 1979

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  • May 10, 2015, 6:16 a.m.

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  • Aug. 10, 2016, 10:26 p.m.

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Michnoff, Carolyn A. Histochemical Characterization of Lymphocytes in Preleukemic and Leukemic AKR Mice, thesis, May 1979; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc503886/: accessed October 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .