The Effects of Long Term Moderate Ethanol Intake on the Immune Response in Rats

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Description

Using a rat model, the effects of a single dose or six to twelve months of daily oral administration of ethanol on the immune system were determined. The rats were challenged with sheep red blood cells after the various dosing periods to elicit an immune response. Immune system responsiveness was determined by means of white blood cell counts and differentials, antibody titers, and T-cell numbers. No deleterious effects of the ethanol on the immune response were seen, while the female alcohol-fed rats showed a significant increase in T-Cell numbers, white blood cell counts, and lymphocytes over the sham group.

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v, 44 leaves

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Follin, Cynthia A. (Cynthia Ann) August 1991.

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  • Follin, Cynthia A. (Cynthia Ann)

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Using a rat model, the effects of a single dose or six to twelve months of daily oral administration of ethanol on the immune system were determined. The rats were challenged with sheep red blood cells after the various dosing periods to elicit an immune response. Immune system responsiveness was determined by means of white blood cell counts and differentials, antibody titers, and T-cell numbers. No deleterious effects of the ethanol on the immune response were seen, while the female alcohol-fed rats showed a significant increase in T-Cell numbers, white blood cell counts, and lymphocytes over the sham group.

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v, 44 leaves

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UNT Theses and Dissertations

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  • August 1991

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  • March 9, 2015, 8:15 a.m.

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  • Sept. 27, 2017, 2:40 p.m.

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Citations, Rights, Re-Use

Follin, Cynthia A. (Cynthia Ann). The Effects of Long Term Moderate Ethanol Intake on the Immune Response in Rats, thesis, August 1991; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc501247/: accessed October 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .