An Investigation of the Ratio of Free to Bound Phenytoin in Overdose Cases

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An investigation of the ratio of free to bound phenytoin in overdose cases was accomplished by three studies to answer these questions: 1. Will the free to bound ratio change with increasing total phenytoin concentration? 2. Will the free to bound ratio be altered with decreasing total protein concentration? 3. Do these results correlate with overdose cases? The results demonstrated that the ratio of free to bound phenytoin remains constant throughout the therapeutic range as long as a person has a normal total protein concentration. However, the free to bound ratio changes significantly when the total protein decreases by 25 ... continued below

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vii, 56 leaves: ill.

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Beckman Royder, Mona Lee August 1985.

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This thesis is part of the collection entitled: UNT Theses and Dissertations and was provided by UNT Libraries to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 16 times . More information about this thesis can be viewed below.

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  • Beckman Royder, Mona Lee

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An investigation of the ratio of free to bound phenytoin in overdose cases was accomplished by three studies to answer these questions: 1. Will the free to bound ratio change with increasing total phenytoin concentration? 2. Will the free to bound ratio be altered with decreasing total protein concentration? 3. Do these results correlate with overdose cases? The results demonstrated that the ratio of free to bound phenytoin remains constant throughout the therapeutic range as long as a person has a normal total protein concentration. However, the free to bound ratio changes significantly when the total protein decreases by 25 per cent. This substantiates the importance of monitoring free and total phenytoin concentrations in hypoproteinemia.

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vii, 56 leaves: ill.

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UNT Theses and Dissertations

Theses and dissertations represent a wealth of scholarly and artistic content created by masters and doctoral students in the degree-seeking process. Some ETDs in this collection are restricted to use by the UNT community.

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  • August 1985

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  • March 9, 2015, 8:15 a.m.

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  • Nov. 30, 2016, 10:54 a.m.

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Citations, Rights, Re-Use

Beckman Royder, Mona Lee. An Investigation of the Ratio of Free to Bound Phenytoin in Overdose Cases, thesis, August 1985; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc501077/: accessed October 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .