The Reproductive Consequences of Carriers of Methylenebisacrylamide-Induced Balanced Reciprocal Translocations in Mus Musculus

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Description

N,N'-methylenebisacrylamide (MBA) was studied because of its effectiveness in inducing heritable translocations in germ cells of male mice. The health impact of translocations was studied through anatomical analysis of the progeny of semisterile translocation carriers. As expected, the semisterility of translocation carriers resulted primarily from embryonic death during periimplantation stages due to unbalanced chromosome sperm segregants. Among conceptuses that survived to mid- and late-gestation stages, there was an increased incidence of developmental anomalies including fetal death and phenotypic defects. These abnormalities are associated with unbalanced chromosome complements that allow survival to the later stages of development.

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vi, 87 leaves: ill.

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Kile, Joanna L. (Joanna Le) May 1989.

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  • Kile, Joanna L. (Joanna Le)

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N,N'-methylenebisacrylamide (MBA) was studied because of its effectiveness in inducing heritable translocations in germ cells of male mice. The health impact of translocations was studied through anatomical analysis of the progeny of semisterile translocation carriers. As expected, the semisterility of translocation carriers resulted primarily from embryonic death during periimplantation stages due to unbalanced chromosome sperm segregants. Among conceptuses that survived to mid- and late-gestation stages, there was an increased incidence of developmental anomalies including fetal death and phenotypic defects. These abnormalities are associated with unbalanced chromosome complements that allow survival to the later stages of development.

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vi, 87 leaves: ill.

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UNT Theses and Dissertations

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  • May 1989

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  • March 9, 2015, 8:15 a.m.

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  • Nov. 29, 2017, 11:15 a.m.

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Citations, Rights, Re-Use

Kile, Joanna L. (Joanna Le). The Reproductive Consequences of Carriers of Methylenebisacrylamide-Induced Balanced Reciprocal Translocations in Mus Musculus, thesis, May 1989; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc500402/: accessed February 25, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .