The Teratogenic Effects of Nocodazole and Acrylamide in Mus Musculus

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In two separate experiments, weight adjusted doses of nocodazole and acrylamide were injected intraperitoneally at various time intervals into twelve week old female mice. Within the nocodazole experiment, the doses were injected at varying time intervals before and after mating. On day seventeen of gestation, the female mice were sacrificed and their uterine contents examined. Nocodazole induced a significant increase in reproductive pathology per total implants when administered one hour after mating to the (SECxC57BL)F, stock: 5.00% total deads, 70.23% moles, and 3.41% abnormal fetuses. Acrylamide treatment produced a significant reduction in live births when administered six hours after mating: ... continued below

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iv, 58 leaves

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Oliva, Jean L. (Jean Louise) May 1989.

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This thesis is part of the collection entitled: UNT Theses and Dissertations and was provided by UNT Libraries to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 21 times , with 5 in the last month . More information about this thesis can be viewed below.

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  • Oliva, Jean L. (Jean Louise)

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In two separate experiments, weight adjusted doses of nocodazole and acrylamide were injected intraperitoneally at various time intervals into twelve week old female mice. Within the nocodazole experiment, the doses were injected at varying time intervals before and after mating. On day seventeen of gestation, the female mice were sacrificed and their uterine contents examined. Nocodazole induced a significant increase in reproductive pathology per total implants when administered one hour after mating to the (SECxC57BL)F, stock: 5.00% total deads, 70.23% moles, and 3.41% abnormal fetuses. Acrylamide treatment produced a significant reduction in live births when administered six hours after mating: 50.86% moles and 46.46% living fetuses per total implants.

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iv, 58 leaves

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UNT Theses and Dissertations

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  • May 1989

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  • March 9, 2015, 8:15 a.m.

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  • Jan. 4, 2018, 8:38 a.m.

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Citations, Rights, Re-Use

Oliva, Jean L. (Jean Louise). The Teratogenic Effects of Nocodazole and Acrylamide in Mus Musculus, thesis, May 1989; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc500254/: accessed January 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .