Tissue-specific Bioconcentration Factor of the Synthetic Steroid Hormone Medroxyprogesterone Acetate (Mpa) in the Common Carp, Cyprinus Carpia

PDF Version Also Available for Download.

Description

Due to the wide spread occurrence of medroxyprogesterone acetate (MPA), a pharmaceutical compound, in wastewater effluent and surface waters, the objectives of this work were to determine the tissue specific uptake and bioconcentration factor (BCF) for MPA in common carp. BCFs were experimentally determined for MPA in fish using a 14-day laboratory test whereby carp where exposed to 100 μg/L of MPA for a 7-day period followed by a depuration phase in which fish were maintained in dechlorinated tap water for an additional 7 days. MPA concentrations in muscle, brain, liver and plasma were determined by liquid chromatography/mass spectrometry (LC/MS). ... continued below

Creation Information

Steele IV, William B. August 2013.

Context

This thesis is part of the collection entitled: UNT Theses and Dissertations and was provided by UNT Libraries to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 182 times , with 12 in the last month . More information about this thesis can be viewed below.

Who

People and organizations associated with either the creation of this thesis or its content.

Publisher

Rights Holder

For guidance see Citations, Rights, Re-Use.

  • Steele IV, William B.

Provided By

UNT Libraries

The UNT Libraries serve the university and community by providing access to physical and online collections, fostering information literacy, supporting academic research, and much, much more.

Contact Us

What

Descriptive information to help identify this thesis. Follow the links below to find similar items on the Digital Library.

Degree Information

Description

Due to the wide spread occurrence of medroxyprogesterone acetate (MPA), a pharmaceutical compound, in wastewater effluent and surface waters, the objectives of this work were to determine the tissue specific uptake and bioconcentration factor (BCF) for MPA in common carp. BCFs were experimentally determined for MPA in fish using a 14-day laboratory test whereby carp where exposed to 100 μg/L of MPA for a 7-day period followed by a depuration phase in which fish were maintained in dechlorinated tap water for an additional 7 days. MPA concentrations in muscle, brain, liver and plasma were determined by liquid chromatography/mass spectrometry (LC/MS). The results from the experiment indicate that MPA can accumulate in fish, however, MPA is not considered to be bioaccumulative based on regulatory standards (BCF ≥ 1000). Although MPA has a low BCF value in common carp, this compound may cause reproductive effects in fish at environmentally relevant concentrations.

Language

Collections

This thesis is part of the following collection of related materials.

UNT Theses and Dissertations

Theses and dissertations represent a wealth of scholarly and artistic content created by masters and doctoral students in the degree-seeking process. Some ETDs in this collection are restricted to use by the UNT community.

What responsibilities do I have when using this thesis?

When

Dates and time periods associated with this thesis.

Creation Date

  • August 2013

Added to The UNT Digital Library

  • March 8, 2015, 5:44 p.m.

Description Last Updated

  • June 27, 2017, 11:22 a.m.

Usage Statistics

When was this thesis last used?

Yesterday: 3
Past 30 days: 12
Total Uses: 182

Interact With This Thesis

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Steele IV, William B. Tissue-specific Bioconcentration Factor of the Synthetic Steroid Hormone Medroxyprogesterone Acetate (Mpa) in the Common Carp, Cyprinus Carpia, thesis, August 2013; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc500141/: accessed April 21, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; .