Chemical versus Pharmacological Actions of Nutraceutical Phytochemicals: Antioxidant and Anti Inflammatory Modalities

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Article on chemical versus pharmacological actions of nutraceutical phytochemicals and antioxidant and anti inflammatory modalities.

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14 p.

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Hensley, Kenneth; Mou, Shenyun; Pye, Quentin N.; Dixon, R. A.; Sumner, Lloyd W. & Floyd, Robert A. 2004.

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Article on chemical versus pharmacological actions of nutraceutical phytochemicals and antioxidant and anti inflammatory modalities.

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14 p.

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Abstract: A variety of polyphenolic phytochemicals have been heavily touted as possessing healthful properties by virtue of their antioxidant ability. Indeed, a growing body of evidence indicates that certain bioflavonoids and dicatechols possess salubrious activity against cardiovascular disease, cancer, and neurodegenerative diseases. Administration of these agents to experimental animals or to humans can result in diminution of oxidative stress indicators, clearly suggesting antioxidant properties. One must, however, consider that concentrations of these phytochemicals in vivo seldom reach levels sufficient to directly scavenge reactive oxygen species (ROS). The apparent paradox may be resolved in recent advances that clarify the relationship between ROS, inflammation, and redox-sensitive signal transduction. It is becoming apparent that ROS production is an inherent aspect of both chronic and acute inflammatory processes. Many common polyphenolic phytochemicals are potent inhibitors of enzyme systems responsible for the generation of ROS and nitric oxide during these periods of inflammation. As a consequence the compounds possess potent and sometimes very specific anti-inflammatory properties. Thus, polyphenolic phytochemicals can rightly be explored as pharmacophores, rational consideration of which might lead to improved bioactivity. These issues are discussed with specific examples involving flavones, isoflavones, stilbenoids and dicatechols that are currently being explored within the nutraceutical industry.

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  • Current Topics in Nutraceutical Research, 2004, Coppell: New Century Health Publishers, pp. 13-26

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  • Publication Title: Current Topics in Nutraceutical Research
  • Volume: 2
  • Issue: 1
  • Page Start: 13
  • Page End: 26
  • Pages: 14
  • Peer Reviewed: Yes

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  • 2004

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  • Jan. 22, 2015, 9:04 a.m.

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Hensley, Kenneth; Mou, Shenyun; Pye, Quentin N.; Dixon, R. A.; Sumner, Lloyd W. & Floyd, Robert A. Chemical versus Pharmacological Actions of Nutraceutical Phytochemicals: Antioxidant and Anti Inflammatory Modalities, article, 2004; [Coppell, Texas]. (digital.library.unt.edu/ark:/67531/metadc488144/: accessed December 10, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.