# Solubility of Tris(hydroxymethyl)aminomethane in Methanol + 1-Propanol Mixtures at Various Temperatures Page: 4,228

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Journal of Chemical & Engineering Data

Table 1. List of the Used Materials

material purity/in mass fraction company country

TRIS: tris(hydroxymethyl)aminomethane (CASRN 77-86-1) 0.999 Merck Germany

MeOH 0.999 Merck Spain

1-PrOH 0.999 Scharlau Germany

Table 2. Experimental Mole Fraction Solubilitya of Tris(hydroxymethyl)aminomethane (TRIS) in Binary Mixtures of MeOH

(1) + 1-PrOH (2) at Various TemperaturesbSD 298.2 K

4.00 x 10-4

2.00 x 10-4

1.00 x 10-4

1.00 x 10-4

1.00 x 10-4

2.00 x 10-4

3.00 x 10-5

1.00 x 10-4

1.00 x 10-4

2.00 x 10-4

2.00 x 10-49.20 x 10-3

8.60 x 10-3

7.80 x 10-3

6.90 x 10-3

6.40 x 10-3

6.00 x 10-3

5.40 x 10-3

5.30 x 10-3

5.20 x 10-3

5.10 x 10-3

5.00 x 10-3SD 303.2 K

3.00 x 10-4

3.00 x 10-4

3.00 x 10-4

1.00 x 10-4

2.00 x 10-4

2.00 x 10-4

1.00 x 10-4

1.00 x 10-4

1.00 x 10-4

4.00 x 10-5

2.00 x 10-41.06 x 10-2

1.03 X 10-2

9.30 x 10-3

8.30 x 10-3

7.70 x 10-3

7.20 x 10-3

6.70 x 10-3

6.60 x 10-3

6.50 x 10-3

6.40 x 10-3

6.30 x 10-3SD 308.2 K

6.00 x 10-4

3.00 x 10-4

3.00 x 10-4

3.00 x 10-4

2.00 x 10-4

3.00 x 10-4

4.00 x 10-5

2.00 x 10-4

1.00 x 10-4

1.00 x 10-4

1.00 x 10-41.24 x 10-2

1.21 X 10-2

1.12 x 10-2

1.00 x 10-2

9.20 x 10-3

8.70 x 10-3

8.00 x 10-3

7.80 x 10-3

7.70 x 10-3

7.40 x 10-3

7.20 x 10-3SD 313.2 K

6.00 x 10-4

2.00 x 10-5

3.00 x 10-4

3.00 x 10-4

1.00 x 10-4

4.00 x 10-4

1.00 x 10-4

1.00 x 10-4

2.00 x 10-4

2.00 x 10-5

4.00 x 10-51.58 x 10-2

1.52 x 10-2

1.38 X 10-2

1.25 x 10-2

1.12 x 10-2

1.04 x 10-2

9.80 x 10-3

9.70 x 10-3

9.60 x 10-3

9.20 x 10-3

8.80 x 10-3"Data are the mean of three measurements. SD: standard deviation. bThe relative standard uncertainty for the solubilities is 2.6% or ur(x) = 0.026,

the standard uncertainty for temperature is 0.1 K and the measurements were made at atmospheric pressure. x is the mole fractions of MeOH in

the absence of TRIS.purity of 0.999) was purchased from Scharlau (Spain). All

reagents were used without further purifications. Table 1 lists

the details of materials used in this work.

Instrumentation. The solute solubility is determined

employing various techniques which are reviewed in a recent

work.8 The common so-called synthetic method9 is based on

the disappearance of the solid solute from the solution as

monitored by a laser beam. A lab-made setup was applied for

the measurement of the solubility of TRIS in MeOH + 1-PrOH

mixtures. It is based on this synthetic method and is described

in earlier works.4''10 Briefly, a syringe filled with TRIS powder

was weighed using an electronic balance (Sartorius, Germany)

with uncertainty of 0.01 g before and after saturation of the

solution (the mass difference determines the mass of solute

dissolved to saturate the solution). In more detail, after

reaching the experimental temperature, the setup added a small

amount of TRIS to a given mass of the solvent and/or solvent

mixture, and the content was stirred continuously at a constant

temperature with the uncertainty of + 0.1 K. As the particles of

TRIS were dissolved, the signals indicating the number of

particles decreased gradually and reached to the minimum value

when TRIS is completely dissolved. Then an additional amount

of TRIS was dispensed to the vessel and the procedure was

repeated until the laser beam could not return to the minimum

value; an indication that the last added portion of powder could

not be dissolved. This cycle was checked several times by the

software, and then the system was stopped and the total

amount of the added drug was recorded and used to calculate

the solubility value. The signals for pure solvents are considered

as the minimum intensity of the signals detected by the photo

converter. Further details of the setup have been provided in

earlier works.4''10 It should be noted that the total masses of

the solvent mixtures were 120 g, and those of the solute plus

the syringe varied between (0.10 and 4.00) g. All measurements

were conducted at atmospheric pressure.

Calculations. The average of measurements carried out at

least in triplicate was used to calculate the mole fraction

solubility of TRIS. The masses (w1 and w2) of solvents 1(MeOH) and 2 (1-PrOH) were divided by their molar masses

(MW1 and MW2), and then the mole fractions of solvents 1

and 2 in the absence of the solute (x and/or x ) were

computed as

Xi

Mwi+MW2=(1)

The saturated mole fraction solubility of TRIS (xmT) at

different compositions of the binary MeOH + 1-PrOH mixtures

at various temperatures was calculated using

WTMSMWTRIS

xmT =

' wmRs + Wl + W2

\MWTRs MW1 MW2 /(2)

where WTRIS and MWTRIS are the mass of TRIS added to

saturate the solution and the molar mass of TRIS, respectively.

Evaluation of the accuracy of the calculated data was performed

by computing the mean percentage deviations (MPD) between

calculated and experimental solubilities according to

(0 calculated experimental

MPD 100 xm,T - xm,T

P experimental

N XmT )(3)

where N is the number of data points in each set.

RESULTS AND DISCUSSION

Table 2 lists the experimental mole fraction solubility of TRIS

at various mole fractions of MeOH (1) + 1-PrOH (2) mixtures

at the temperatures investigated. The solubility of TRIS in the

monosolvents and at each solvent composition increased with

increasing temperature. This is an expected solubility pattern

for such type of solid solutes in the solutions. The mole fraction

solubility of TRIS in a given solvent system at various

temperatures (XT) could be represented using the van't Hoff

equation"dx.doi.org/10.1021/je5009685 I J. Chem. Eng. Data 2014, 59, 4227-4230

xc 293.2 K

1.00

0.94

0.88

0.81

0.74

0.65

0.56

0.45

0.32

0.17

0.007.60 x 10-3

7.10 x 10-3

6.40 x 10-3

5.80 x 10-3

5.30 x 10-3

5.00 x 10-3

4.40 x 10-3

4.30 x 10-3

4.10 x 10-3

3.90 x 10-3

3.80 x 10-3SD

7.00 x 10-4

1.00 x 10-4

5.00 x 10-4

5.00 x 10-4

1.00 x 10-4

5.00 x 10-4

1.00 x 10-4

4.00 x 10-4

4.00 x 10-4

6.00 x 10-4

1.00 x 10-44228

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Jouyban-Gharamaleki, Vahid; Jouyban-Gharamaleki, Karim; Soleymani, Jafar; Kenndler, Ernst; Acree, William E. (William Eugene) & Jouyban, Abolghasem. Solubility of Tris(hydroxymethyl)aminomethane in Methanol + 1-Propanol Mixtures at Various Temperatures, article, November 26, 2014; [Washington, D.C.]. (digital.library.unt.edu/ark:/67531/metadc485913/m1/2/: accessed November 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.