The Effect of Menthol on Nicotine Metabolism: a Cross Species Evaluation

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The effect of menthol on nicotine metabolism was examined in liver S9 fractions of four different species and in the in vivo mouse model. The purpose of this study was to investigate three parameters: (1) biotransformation of nicotine to cotinine in various species (human, mouse, rat and trout) using in vitro methods; (2) to determine if the addition of menthol with nicotine altered biotransformation of nicotine to cotinine; (3) and to assess similar parameters in an in vivo mouse model. The major findings of this study include: (1) mice appear to metabolize nicotine, over time, in a manner similar to ... continued below

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Pace, Wendy Lee December 2013.

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  • Pace, Wendy Lee

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The effect of menthol on nicotine metabolism was examined in liver S9 fractions of four different species and in the in vivo mouse model. The purpose of this study was to investigate three parameters: (1) biotransformation of nicotine to cotinine in various species (human, mouse, rat and trout) using in vitro methods; (2) to determine if the addition of menthol with nicotine altered biotransformation of nicotine to cotinine; (3) and to assess similar parameters in an in vivo mouse model. The major findings of this study include: (1) mice appear to metabolize nicotine, over time, in a manner similar to humans; (2) menthol decreased cotinine production, over time, after a single dose in mice; and (3) menthol increased cotinine production, over time, after repeated doses, in mice.

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  • December 2013

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  • Nov. 8, 2014, 11:56 a.m.

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  • June 27, 2017, 11:16 a.m.

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Pace, Wendy Lee. The Effect of Menthol on Nicotine Metabolism: a Cross Species Evaluation, thesis, December 2013; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc407773/: accessed July 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .